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Welcome to Live Well with UCI Health.

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My name is Gina Grad.

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I'm from ALT 98.7 and iHeartRadio,

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and I would like to welcome

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a very special guest today,

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Doctor Alexandra Lopez Aguilar.

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She's a board-certified

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surgical oncologist

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with advanced training

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in breast cancer surgery.

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And, as if that wasn't enough,

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is an assistant professor

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for the Department of Surgery

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at UC Irvine School of Medicine.

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Doctor, thank you so much for being here.

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Thank you for having me.

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We really appreciate it

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and there's so much to learn from you.

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I know we've come a long way

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when it comes to treating breast cancer.

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And I mean, even from,

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you know, my own family members

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to friends nowadays,

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I can I,

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I just hear about

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all the technological advances.

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I bet it's very, very interesting

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to see all the progress

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that's been made in

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what feels like kind of a short time.

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Yes. Absolutely. It...

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So if you go back to like the 1800s.

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They were doing.

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What's called a radical mastectomy

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to treat breast cancer,

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where you were

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removing the entire breast,

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all of the lymph nodes in the axilla

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and the muscle.

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So these were

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really disfiguring surgeries.

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These were horrible.

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And this was done for decades.

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It really wasn't until the 1970s,

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which is wild

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because that's not that long ago,

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or at least doesn't feel like

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it was that long ago.

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No, no, no, no, no, no.

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So, for basically, like, a hundred years

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this was the standard. Yes.

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And then we started

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moving away from that, doing things

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like modified radical mastectomies

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and then starting to really do

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like toward, you know, 80s, 90s,

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we started seeing things like lumpectomies

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come onto the page with radiation.

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And now we've gone

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from when you would remove

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all of the lymph nodes

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to really in a good portion of patients

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don't even have to have their,

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their sentinel lymph

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nodes checked anymore. Why?

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What's the difference?

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We've seen that

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especially in patients

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who are post-menopausal,

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who are hormone positive

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and have really small breast cancers...

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We've done studies in really

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just the last two years

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that show that the sentinel nodes

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don't really add that much,

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because vast majority

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of the time they're negative.

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So you don't have to necessarily

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put that population of patients

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through that extra procedure.

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And when you compare that

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to what we used to do in the past,

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it's wild how much it's changed.

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So it's really great

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about not necessarily having to do

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sampling in the axilla

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is, while it's just a small addition

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to the surgery

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that the patient's

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already having their lumpectomy,

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or their mastectomy,

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sentinel lymph node

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biopsies aren't without risk

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because these are,

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these patients can still have

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a very small risk of lymphedema.

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And that's where the arm can get swollen...

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And stay swollen? And could stay swollen.

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And many times

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we can do things to mitigate it,

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but it can stay swollen.

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And so if you ever see patients

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with large arms and

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sleeves on, that's... Like a compression sleeve. That's...

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Exactly, exactly.

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So they can have that.

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They can have pain.

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A lot of patients,

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just the discomfort

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of having the incision over

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there can take a little longer recovery.

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They can have some numbness.

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They can get something

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called axillary cording

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where you get this band of tissue

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that can kind of sit right at the axilla

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and sometimes extend down the arm.

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So these are, 

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complications are not common,

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but they're not nonexistent. There are risks.

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Exactly.

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So anything that you can do that

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lessens that risk is wonderful

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for the patient.

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That's so interesting.

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Did we just not know to look for that?

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Or we needed a big enough

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sample size to realize, hey,

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this isn't really making a difference?

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Yes.

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So it's really,

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I think just the numbers and time

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to get data to show

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that these patients aren't

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having really high recurrence rates,

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that doing more surgery doesn't

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necessarily mean better outcomes,

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and it just

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sometimes takes a little longer.

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But the good news is breast

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is like

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10, 15 years

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ahead of most other oncology specialties

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because there's just so

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much, there's so much buy-in,

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and there's so many people

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who are interested in breast

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and, and getting,

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you know, funding for breast research.

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So we're really doing

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well in terms of like pushing the needle.

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That's awesome. And that's so heartening to hear because,

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you know,

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the joke is like,

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well, we're going to cure baldness

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before we cure anything for women. Yes.

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So to hear you say that we're ahead of

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the game is, is really wonderful news.

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Yeah I know there's,

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you know,

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obviously different stages

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of breast cancer and different kinds.

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I am wondering

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what the typical treatments are

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for somebody

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who is diagnosed with breast cancer.

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And I'm sure there's many options.

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Yes.

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So when somebody presents to clinic

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with a new breast cancer diagnosis,

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I usually tell them that this is a very,

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very multidisciplinary management of it

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because surgery, which as a surgeon,

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you know,

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is what I offer... Right.

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Is a huge portion

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of what we offer patients.

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But then there's also radiation

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that might be on the table,

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endocrine therapy

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might be on the table or hormone blockade

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and then sometimes chemotherapy.

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So usually it's some mix

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of those four things.

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And then we tailor

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it based on the individual needs

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of that patient

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and specific

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things that we see in their cancer.

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So we look at their receptors.

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Is this an estrogen

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positive progesterone positive,

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or a HER2 positive cancer.

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Because all of those things

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will affect our choice.

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And if they get chemo

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or if they get endocrine therapy.

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I've heard this before.

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I don't know anyone personally,

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and you don't hear about it in the news

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or anything, but true or false,

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men can also get breast cancer? True.

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Not common.

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Actually

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it accounts for less

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than 1% of breast cancers.

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But it happens. It does.

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And you do want to test

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for genetic mutations in these patients,

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because a man who presents with breast

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cancer is a little bit

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more likely to have

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something called the BRCA2

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mutation. Okay.

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So you want to check for that.

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Oh, I've heard of that,

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the BRCA, okay, yeah.

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Yeah.

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So, but these are very,

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very uncommon cases.

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But, so that's why

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you always encourage men

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that if they were to feel any changes,

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they'll present the same way

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they'll present

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with a lump in their breast.

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They could present with

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bloody nipple discharge.

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They can

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present with redness, inflammation.

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So anything that seems alarming to them,

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they should really present

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and get a mammogram.

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And then it's the same thing

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that you would do for a woman.

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They're still,

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in the past

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they used to do mastectomies for them for

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you know, any, any

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you know,

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somebody who comes off the street

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with a new breast cancer

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in a male would get a mastectomy.

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Now, we recognize

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that you can actually treat

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these patients with lumpectomy

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and radiation as well.

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Oh, wow.

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And I would think

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if for as uncommon as it is,

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it would actually be easier to tell

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because you're just dealing

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with less surface area with changes.

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Yeah.

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So more often than not,

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you can palpate their masses

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when they come in.

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These aren't ones that are detected

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with screening mammograms

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like you're seeing with women,

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because there's still

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there's not enough,

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patients who have male breast cancer

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to warrant doing a mammogram

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screening yearly.

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And by the way, I know I'm, I'm speaking

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just from my own experience,

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but I have heard,

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you know,

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growing up,

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just horror stories of how horrible

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and how painful mammograms are.

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They are not a big deal.

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Now, apologies to anyone

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who's not experiencing

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what I'm experiencing,

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but I'm just like,

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yeah, like it's

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not like a trick

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when like the doctor, the dentist is like,

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you're going to feel a little pressure

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and like,

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rips your gums open.

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You feel some pressure

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and then you move on.

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Yeah. It's not...

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I just feel like

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I don't want anybody

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to be too intimidated to

290
00:06:54,633 --> 00:06:55,566
have a mammogram,

291
00:06:55,566 --> 00:06:57,566
because it is just, in my experience,

292
00:06:57,566 --> 00:06:59,033
it is just not that bad.

293
00:06:59,033 --> 00:06:59,566
I agree

294
00:06:59,566 --> 00:07:00,733
they're not comfortable

295
00:07:00,733 --> 00:07:01,633
and I never tell anybody

296
00:07:01,633 --> 00:07:03,133
you're going to be comfortable,

297
00:07:03,133 --> 00:07:04,766
but it's over quickly

298
00:07:04,766 --> 00:07:07,033
and it can save your life. Yeah.

299
00:07:07,033 --> 00:07:08,233
And I think the other thing

300
00:07:08,233 --> 00:07:09,533
that people will often come

301
00:07:09,533 --> 00:07:10,166
concerned about

302
00:07:10,166 --> 00:07:11,566
is how much radiation exposure

303
00:07:11,566 --> 00:07:12,433
they're going to get.

304
00:07:12,433 --> 00:07:13,966
It's basically the equivalent

305
00:07:13,966 --> 00:07:15,833
of flying across the country

306
00:07:15,833 --> 00:07:16,433
on an airplane.

307
00:07:16,433 --> 00:07:17,066
Oh, I never actually

308
00:07:17,066 --> 00:07:18,333
So it's like a round-trip

309
00:07:18,333 --> 00:07:19,133
across the country. I never actually thought about that.

310
00:07:19,133 --> 00:07:20,566
So it's the same amount of radiation

311
00:07:20,566 --> 00:07:21,633
as doing that. Yeah.

312
00:07:21,633 --> 00:07:23,333
So that worry

313
00:07:23,333 --> 00:07:24,766
that this radiation exposure

314
00:07:24,766 --> 00:07:26,566
is going to be bad for you long term...

315
00:07:26,566 --> 00:07:27,866
You'll get one business

316
00:07:27,866 --> 00:07:30,833
trip of radiation. Yeah. Okay. Got it.

317
00:07:30,833 --> 00:07:32,533
Put it in terms we can all understand.

318
00:07:32,533 --> 00:07:32,833
Yeah.

319
00:07:32,833 --> 00:07:34,766
So when you first see a patient

320
00:07:34,766 --> 00:07:36,366
who's been diagnosed with breast cancer,

321
00:07:36,366 --> 00:07:38,133
how do you prepare them

322
00:07:38,133 --> 00:07:39,133
for what they're about to face?

323
00:07:39,133 --> 00:07:41,133
Because I imagine they're very scared.

324
00:07:41,133 --> 00:07:41,866
They, you know,

325
00:07:41,866 --> 00:07:42,833
the unknown

326
00:07:42,833 --> 00:07:45,133
is the most scary to most of us.

327
00:07:45,133 --> 00:07:47,233
So how do you,

328
00:07:47,233 --> 00:07:48,933
how do you emotionally

329
00:07:48,933 --> 00:07:50,166
and psychologically

330
00:07:50,166 --> 00:07:51,733
prepare them for what's to come?

331
00:07:51,733 --> 00:07:52,633
Yeah,

332
00:07:52,633 --> 00:07:54,233
it's tough because it is really,

333
00:07:54,233 --> 00:07:55,433
really vulnerable time.

334
00:07:55,433 --> 00:07:56,766
And I'm sure it's very different

335
00:07:56,766 --> 00:07:57,633
for every person.

336
00:07:57,633 --> 00:07:59,233
So there isn't just a one size fits all.

337
00:07:59,233 --> 00:08:00,133
Absolutely.

338
00:08:00,133 --> 00:08:01,833
But I try to contextualize it.

339
00:08:01,833 --> 00:08:05,133
I try to emphasize that this is a disease

340
00:08:05,133 --> 00:08:07,033
that is incredibly survivable.

341
00:08:07,033 --> 00:08:10,233
We're talking 97, 98%, five,

342
00:08:10,233 --> 00:08:11,833
ten-year survival for patients

343
00:08:11,833 --> 00:08:13,533
with early-stage breast cancer.

344
00:08:13,533 --> 00:08:14,233
You know, drops

345
00:08:14,233 --> 00:08:14,633
a little bit

346
00:08:14,633 --> 00:08:15,766
if you've got metastasized

347
00:08:15,766 --> 00:08:16,533
to the lymph nodes.

348
00:08:16,533 --> 00:08:18,166
But metastasis to the lymph nodes,

349
00:08:18,166 --> 00:08:19,633
even in that case,

350
00:08:19,633 --> 00:08:21,833
it's still at 87%,

351
00:08:21,833 --> 00:08:23,366
you know, relative survival.

352
00:08:23,366 --> 00:08:24,233
So it's really

353
00:08:24,233 --> 00:08:26,633
you're not seeing low numbers in survival

354
00:08:26,633 --> 00:08:27,566
until you start hitting

355
00:08:27,566 --> 00:08:29,033
the distant metastases.

356
00:08:29,033 --> 00:08:30,566
And what

357
00:08:30,566 --> 00:08:31,733
just for us lay people

358
00:08:31,733 --> 00:08:33,333
like when it says stage one, stage two.

359
00:08:33,333 --> 00:08:34,966
What, what stage would you say

360
00:08:34,966 --> 00:08:37,133
is when the number...

361
00:08:37,133 --> 00:08:38,766
where it starts to fall off? Stage four.

362
00:08:38,766 --> 00:08:40,233
So when you start seeing that

363
00:08:40,233 --> 00:08:41,733
the cancer's spread to bone

364
00:08:41,733 --> 00:08:43,933
to liver, to brain, to lungs, whatever...

365
00:08:43,933 --> 00:08:45,533
And that's what stage four means. Correct. It's spread.

366
00:08:45,533 --> 00:08:46,733
It's spread, and spread

367
00:08:46,733 --> 00:08:47,733
not just to

368
00:08:47,733 --> 00:08:49,033
the lymph nodes in the axilla,

369
00:08:49,033 --> 00:08:50,533
but elsewhere in the body.

370
00:08:50,533 --> 00:08:51,033
Okay.

371
00:08:51,033 --> 00:08:53,166
But even those patients can actually

372
00:08:53,166 --> 00:08:54,133
be controlled.

373
00:08:54,133 --> 00:08:55,233
What we say

374
00:08:55,233 --> 00:08:56,633
when they first walk through the door

375
00:08:56,633 --> 00:08:57,966
and they have basically stage

376
00:08:57,966 --> 00:08:59,133
one through three,

377
00:08:59,133 --> 00:09:01,033
it is still curable at that point.

378
00:09:01,033 --> 00:09:02,833
You can rid that patient of the cancer,

379
00:09:02,833 --> 00:09:03,433
which is another thing

380
00:09:03,433 --> 00:09:05,333
I like to focus on for patients,

381
00:09:05,333 --> 00:09:06,633
is to let them know

382
00:09:06,633 --> 00:09:07,766
this is a problem,

383
00:09:07,766 --> 00:09:09,433
but this is a treatable problem.

384
00:09:09,433 --> 00:09:11,433
And, you know,

385
00:09:11,433 --> 00:09:12,433
for most patients

386
00:09:12,433 --> 00:09:14,133
in not more than a year,

387
00:09:14,133 --> 00:09:15,033
you're going to be done with this.

388
00:09:15,033 --> 00:09:16,633
And this is going to be a bad memory.

389
00:09:16,633 --> 00:09:18,033
Right.

390
00:09:18,033 --> 00:09:20,233
With stage four, it's more about

391
00:09:20,233 --> 00:09:21,633
we can control this now.

392
00:09:21,633 --> 00:09:23,333
We can control this with treatment.

393
00:09:23,333 --> 00:09:24,133
But you're now living

394
00:09:24,133 --> 00:09:25,833
with a chronic disease. Okay.

395
00:09:25,833 --> 00:09:26,633
And a disease

396
00:09:26,633 --> 00:09:28,433
that may kill you in the long term,

397
00:09:28,433 --> 00:09:30,933
but is, is still pretty controllable.

398
00:09:30,933 --> 00:09:32,633
And we've seen people 10 years out

399
00:09:32,633 --> 00:09:33,533
with stage four

400
00:09:33,533 --> 00:09:34,133
that are still...

401
00:09:34,133 --> 00:09:35,433
That are living with stage four. Yeah.

402
00:09:35,433 --> 00:09:38,033
That's so interesting because, you know,

403
00:09:38,033 --> 00:09:39,333
most of us don't understand

404
00:09:39,333 --> 00:09:41,166
what each stage represents.

405
00:09:41,166 --> 00:09:42,733
And to know that,

406
00:09:42,733 --> 00:09:44,366
you know, up to stage three,

407
00:09:44,366 --> 00:09:46,366
this means it's still contained...

408
00:09:46,366 --> 00:09:48,133
For the most part. Yeah. Okay.

409
00:09:48,133 --> 00:09:50,333
And then, do we

410
00:09:50,333 --> 00:09:52,166
and like you said, it can be cured.

411
00:09:52,166 --> 00:09:54,133
You're not just living in remission.

412
00:09:54,133 --> 00:09:55,733
You're cured. You're cured.

413
00:09:55,733 --> 00:09:56,933
So when we say remission

414
00:09:56,933 --> 00:09:59,933
and cure, it's, they're synonymous. Remission,

415
00:10:00,233 --> 00:10:01,733
for all intents and purposes,

416
00:10:01,733 --> 00:10:03,033
you have no residual disease.

417
00:10:03,033 --> 00:10:03,933
There's no evidence

418
00:10:03,933 --> 00:10:04,966
that you have anything in your

419
00:10:04,966 --> 00:10:06,166
body. I see. Remission always

420
00:10:06,166 --> 00:10:06,933
seems like something's

421
00:10:06,933 --> 00:10:08,533
lurking in the corner.

422
00:10:08,533 --> 00:10:10,333
Cure is a much better word, right? Yes.

423
00:10:10,333 --> 00:10:12,166
That's why I prefer to use the word cure.

424
00:10:12,166 --> 00:10:14,033
Because I think, you know,

425
00:10:14,033 --> 00:10:14,933
if there's a cell

426
00:10:14,933 --> 00:10:16,333
floating around somewhere...

427
00:10:16,333 --> 00:10:18,533
Yeah. And it's not causing any problems,

428
00:10:18,533 --> 00:10:19,833
you're still,

429
00:10:19,833 --> 00:10:20,333
you're cured.

430
00:10:20,333 --> 00:10:20,533
Yeah.

431
00:10:20,533 --> 00:10:21,233
There's nothing there.

432
00:10:21,233 --> 00:10:22,733
That makes perfect sense.

433
00:10:22,733 --> 00:10:23,833
So what should a patient

434
00:10:23,833 --> 00:10:24,633
know when weighing

435
00:10:24,633 --> 00:10:25,566
whether to have

436
00:10:25,566 --> 00:10:28,433
a breast-conserving lumpectomy,

437
00:10:28,433 --> 00:10:30,033
a full mastectomy?

438
00:10:30,966 --> 00:10:33,166
I, at this age, I

439
00:10:33,166 --> 00:10:34,633
now know several women who...

440
00:10:34,633 --> 00:10:36,366
Now it's a little bit funny.

441
00:10:36,366 --> 00:10:37,333
They said, well,

442
00:10:37,333 --> 00:10:39,233
you know, the bright side is,

443
00:10:39,233 --> 00:10:39,433
you know,

444
00:10:39,433 --> 00:10:40,433
I had a mastectomy,

445
00:10:40,433 --> 00:10:41,566
but I got implants

446
00:10:41,566 --> 00:10:43,533
and I got to pick my size. Yes.

447
00:10:43,533 --> 00:10:44,833
Yeah. Thought that was pretty funny.

448
00:10:44,833 --> 00:10:46,433
So how do you decide?

449
00:10:46,433 --> 00:10:48,133
It's a very personal decision.

450
00:10:48,133 --> 00:10:48,533
And this is,

451
00:10:48,533 --> 00:10:51,533
I think, another area where breast

452
00:10:51,733 --> 00:10:54,333
surgery... or we've just come a long way

453
00:10:54,333 --> 00:10:56,033
because I think medicine

454
00:10:56,033 --> 00:10:56,433
used to be

455
00:10:56,433 --> 00:10:58,566
a lot more paternalistic in the past.

456
00:10:58,566 --> 00:11:00,833
And now there's a lot more teamwork

457
00:11:00,833 --> 00:11:02,733
involved in decision making and care.

458
00:11:02,733 --> 00:11:05,566
After all, it's your body, your choice.

459
00:11:05,566 --> 00:11:06,533
We're not going to do anything

460
00:11:06,533 --> 00:11:09,333
that you're not on board with.

461
00:11:09,333 --> 00:11:10,233
So I say this is, it's

462
00:11:10,233 --> 00:11:11,433
a very personal decision

463
00:11:11,433 --> 00:11:12,333
because patients will

464
00:11:12,333 --> 00:11:13,133
sometimes come in

465
00:11:13,133 --> 00:11:15,633
with preconceived notions of,

466
00:11:15,633 --> 00:11:16,733
I want to just completely

467
00:11:16,733 --> 00:11:17,533
remove my breast,

468
00:11:17,533 --> 00:11:18,633
or I absolutely

469
00:11:18,633 --> 00:11:20,033
do not want to remove my breast.

470
00:11:20,033 --> 00:11:21,133
Please do the least amount

471
00:11:21,133 --> 00:11:22,566
of surgery as possible.

472
00:11:22,566 --> 00:11:23,733
And you can usually work

473
00:11:23,733 --> 00:11:25,133
with both options.

474
00:11:26,333 --> 00:11:26,933
There are

475
00:11:26,933 --> 00:11:27,933
some scenarios

476
00:11:27,933 --> 00:11:29,833
where mastectomy is necessary,

477
00:11:29,833 --> 00:11:30,733
and usually I'll tell

478
00:11:30,733 --> 00:11:31,633
patients it's,

479
00:11:31,633 --> 00:11:33,566
if there is a very high tumor-

480
00:11:33,566 --> 00:11:34,733
to-breast ratio,

481
00:11:34,733 --> 00:11:37,033
meaning this tumor is really large

482
00:11:37,033 --> 00:11:38,833
for the size of your breast,

483
00:11:38,833 --> 00:11:40,366
a lumpectomy is not so much

484
00:11:40,366 --> 00:11:41,433
on the table anymore,

485
00:11:41,433 --> 00:11:42,833
because you're just not going to be

486
00:11:42,833 --> 00:11:43,433
able to.

487
00:11:43,433 --> 00:11:44,566
There's not going to be enough

488
00:11:44,566 --> 00:11:45,933
not, non-diseased

489
00:11:45,933 --> 00:11:47,933
tissue left over to have a breast. Sure.

490
00:11:47,933 --> 00:11:49,433
And so that's where

491
00:11:49,433 --> 00:11:51,133
your hands are a little bit more tied

492
00:11:51,133 --> 00:11:52,033
in terms of what to do.

493
00:11:52,033 --> 00:11:53,833
But outside of that, it's

494
00:11:53,833 --> 00:11:55,933
very much about patient preference. Wow.

495
00:11:55,933 --> 00:11:56,433
And so,

496
00:11:56,433 --> 00:11:57,733
but I'll explain to patients

497
00:11:57,733 --> 00:12:01,033
that a lumpectomy followed by radiation

498
00:12:01,033 --> 00:12:03,233
has the same recurrence risk

499
00:12:03,233 --> 00:12:04,533
as a mastectomy.

500
00:12:04,533 --> 00:12:06,733
Oh. But if you're not willing

501
00:12:06,733 --> 00:12:09,733
to go, undergo radiation post-op

502
00:12:09,766 --> 00:12:11,433
then that plays... Mastectomy is a better option.

503
00:12:11,433 --> 00:12:12,566
Then maybe a mastectomy

504
00:12:12,566 --> 00:12:13,966
is a better option for you to decrease

505
00:12:13,966 --> 00:12:15,433
your local recurrence rate.

506
00:12:15,433 --> 00:12:17,166
But, but yeah, what's nice is

507
00:12:17,166 --> 00:12:18,966
they have the same recurrence rate.

508
00:12:18,966 --> 00:12:20,833
So a lot of patients

509
00:12:20,833 --> 00:12:23,833
will choose to do lumpectomy because

510
00:12:23,933 --> 00:12:25,033
easier recovery,

511
00:12:26,233 --> 00:12:28,733
less surgery, less pain.

512
00:12:28,733 --> 00:12:30,533
So it's it's a little bit

513
00:12:30,533 --> 00:12:31,133
a little bit easier

514
00:12:31,133 --> 00:12:32,966
to have the same ultimate outcome.

515
00:12:32,966 --> 00:12:35,833
I have what I am going to get out

516
00:12:35,833 --> 00:12:36,333
in front of

517
00:12:36,333 --> 00:12:39,433
and say is a very stupid question.

518
00:12:39,633 --> 00:12:40,233
No such thing.

519
00:12:40,233 --> 00:12:43,166
Oh, challenge accepted.

520
00:12:43,166 --> 00:12:43,566
Okay.

521
00:12:43,566 --> 00:12:46,633
So I truly don't know

522
00:12:46,633 --> 00:12:47,133
the difference

523
00:12:47,133 --> 00:12:49,233
between chemotherapy and radiation.

524
00:12:49,233 --> 00:12:50,733
What is the difference?

525
00:12:50,733 --> 00:12:51,166
Of course.

526
00:12:51,166 --> 00:12:54,333
So chemotherapy is a systemic treatment

527
00:12:54,333 --> 00:12:56,033
that we give for breast cancer

528
00:12:56,033 --> 00:12:58,033
or really any other type of cancer.

529
00:12:58,033 --> 00:12:59,933
The radiation that we talk about

530
00:12:59,933 --> 00:13:00,833
when we talk about radiation

531
00:13:00,833 --> 00:13:02,966
in breast cancer is a local therapy.

532
00:13:02,966 --> 00:13:03,366
Okay.

533
00:13:03,366 --> 00:13:04,133
So when you think

534
00:13:04,133 --> 00:13:05,233
about the different things

535
00:13:05,233 --> 00:13:06,333
that we offer patients

536
00:13:06,333 --> 00:13:06,966
who walk in the door

537
00:13:06,966 --> 00:13:07,833
with a breast cancer,

538
00:13:07,833 --> 00:13:09,633
of the four main things that we do ––

539
00:13:09,633 --> 00:13:11,133
surgery, radiation,

540
00:13:11,133 --> 00:13:13,733
chemotherapy and endocrine therapy... Okay.

541
00:13:13,733 --> 00:13:15,033
Surgery and radiation

542
00:13:15,033 --> 00:13:16,333
are local therapies.

543
00:13:16,333 --> 00:13:16,766
They are to

544
00:13:16,766 --> 00:13:19,166
prevent the... They're there to treat the cancer

545
00:13:19,166 --> 00:13:20,633
and prevent it from coming back

546
00:13:20,633 --> 00:13:23,333
in that spot in the breast. Okay. Okay?

547
00:13:23,333 --> 00:13:25,233
And then the

548
00:13:25,233 --> 00:13:26,233
endocrine therapy

549
00:13:26,233 --> 00:13:27,333
and the chemotherapy

550
00:13:27,333 --> 00:13:28,833
are systemic treatments. Whole body...

551
00:13:28,833 --> 00:13:30,833
Endocrine therapy is a pill that you take

552
00:13:30,833 --> 00:13:31,933
and that blocks hormones.

553
00:13:31,933 --> 00:13:32,833
So if you had a hormone

554
00:13:32,833 --> 00:13:33,966
positive breast cancer

555
00:13:33,966 --> 00:13:35,133
it decreases the chance

556
00:13:35,133 --> 00:13:36,366
that that tries to come back.

557
00:13:36,366 --> 00:13:37,733
But it's treating the whole body.

558
00:13:37,733 --> 00:13:38,333
I see.

559
00:13:38,333 --> 00:13:41,166
Chemotherapy is treating the whole body

560
00:13:41,166 --> 00:13:43,966
for, whether it's targeted or... Thank you.

561
00:13:45,133 --> 00:13:46,033
Oh I can,

562
00:13:46,033 --> 00:13:47,133
I can finally be free

563
00:13:47,133 --> 00:13:48,633
of not knowing the answer to that.

564
00:13:48,633 --> 00:13:50,333
That really does help a lot. Yeah.

565
00:13:50,333 --> 00:13:51,233
So we talked about

566
00:13:51,233 --> 00:13:52,333
you know, obviously

567
00:13:52,333 --> 00:13:54,333
the progress we've made from the 1800s,

568
00:13:54,333 --> 00:13:54,733
but what

569
00:13:54,733 --> 00:13:55,933
new surgical procedures

570
00:13:55,933 --> 00:13:57,233
and techniques are available

571
00:13:57,233 --> 00:13:58,766
now that maybe weren't available before,

572
00:13:58,766 --> 00:14:01,433
and do we offer them here at UCI?

573
00:14:01,433 --> 00:14:03,933
So, so I think a lot has, has changed.

574
00:14:03,933 --> 00:14:04,766
Now we offer

575
00:14:04,766 --> 00:14:05,933
things called targeted

576
00:14:05,933 --> 00:14:07,033
axillary dissections

577
00:14:07,033 --> 00:14:08,166
where if somebody presents

578
00:14:08,166 --> 00:14:09,766
with positive lymph nodes,

579
00:14:09,766 --> 00:14:10,433
when they,

580
00:14:10,433 --> 00:14:11,633
when they first present,

581
00:14:11,633 --> 00:14:13,633
we'll clip the node that was positive.

582
00:14:13,633 --> 00:14:15,366
And then after they receive

583
00:14:15,366 --> 00:14:16,933
neoadjuvant chemotherapy

584
00:14:16,933 --> 00:14:19,333
during surgery, we'll remove that node.

585
00:14:19,333 --> 00:14:20,533
So we've had it marked.

586
00:14:20,533 --> 00:14:22,533
We send it to pathology at that time.

587
00:14:22,533 --> 00:14:23,833
Have them look at it.

588
00:14:23,833 --> 00:14:25,633
And if, when they look at it

589
00:14:25,633 --> 00:14:27,333
there's no cancer left behind,

590
00:14:27,333 --> 00:14:28,333
we spare that patient

591
00:14:28,333 --> 00:14:30,633
an axillary dissection. They're done.

592
00:14:30,633 --> 00:14:31,233
Wow. Whereas before

593
00:14:31,233 --> 00:14:32,833
if they presented with lymph nodes

594
00:14:32,833 --> 00:14:34,766
that were positive at the get-go,

595
00:14:34,766 --> 00:14:35,833
they were pretty committed

596
00:14:35,833 --> 00:14:37,566
to an axillary dissection.

597
00:14:37,566 --> 00:14:39,133
So that's... How new is this?

598
00:14:39,133 --> 00:14:40,333
This has probably been

599
00:14:40,333 --> 00:14:42,166
maybe the last 10 years or so.

600
00:14:42,166 --> 00:14:43,966
Oh wow. Yeah, it's, it is, it is

601
00:14:45,133 --> 00:14:48,633
not really super, super new or super old.

602
00:14:48,733 --> 00:14:50,366
That's very interesting. Yeah.

603
00:14:50,366 --> 00:14:51,666
So I've read that lymphedema

604
00:14:51,666 --> 00:14:52,666
is a side effect

605
00:14:52,666 --> 00:14:53,566
for many breast cancer

606
00:14:53,566 --> 00:14:55,266
patients after surgery.

607
00:14:55,266 --> 00:14:57,466
So what is that? How do we treat it?

608
00:14:57,466 --> 00:14:58,666
What do we do about that?

609
00:14:58,666 --> 00:15:00,066
Yeah. Good question.

610
00:15:00,066 --> 00:15:02,600
So lymphedema we'll see...

611
00:15:02,600 --> 00:15:04,266
You have about a 20 to 30%

612
00:15:04,266 --> 00:15:05,600
risk of getting lymphedema

613
00:15:05,600 --> 00:15:07,366
if you're doing an axillary dissection.

614
00:15:07,366 --> 00:15:07,666
Okay.

615
00:15:07,666 --> 00:15:09,000
If you're just doing a sentinel lymph

616
00:15:09,000 --> 00:15:09,566
node biopsy,

617
00:15:09,566 --> 00:15:10,200
which is what we're doing

618
00:15:10,200 --> 00:15:11,466
the vast majority of the time,

619
00:15:11,466 --> 00:15:12,566
your risk is like somewhere

620
00:15:12,566 --> 00:15:13,666
between 5 to 10%.

621
00:15:13,666 --> 00:15:15,266
So very low risk for just an

622
00:15:15,266 --> 00:15:16,400
axillary sentinel node.

623
00:15:16,400 --> 00:15:18,766
But that's part of why we're so excited

624
00:15:18,766 --> 00:15:19,866
in the breast community

625
00:15:19,866 --> 00:15:20,366
that we're

626
00:15:20,366 --> 00:15:21,766
kind of like trying to de-escalate

627
00:15:21,766 --> 00:15:23,566
how much we're going in the X-ray,

628
00:15:23,566 --> 00:15:26,366
because even a small axillary dissection,

629
00:15:26,366 --> 00:15:27,966
it's not without risk.

630
00:15:27,966 --> 00:15:28,166
Right?

631
00:15:28,166 --> 00:15:30,366
Everything. But axillary dissection,

632
00:15:30,366 --> 00:15:30,866
more risk.

633
00:15:30,866 --> 00:15:31,800
So you've got about a 20

634
00:15:31,800 --> 00:15:33,266
to 30% risk of lymphedema.

635
00:15:33,266 --> 00:15:34,466
And what that is,

636
00:15:34,466 --> 00:15:35,666
or the way that it presents is

637
00:15:35,666 --> 00:15:37,966
you'll get swelling in that arm.

638
00:15:37,966 --> 00:15:39,066
So if you've ever seen somebody

639
00:15:39,066 --> 00:15:39,766
that has a

640
00:15:39,766 --> 00:15:40,766
large arm on one side

641
00:15:40,766 --> 00:15:41,566
compared to the other,

642
00:15:41,566 --> 00:15:43,666
that's often lymphedema.

643
00:15:43,666 --> 00:15:45,666
And so slightly more prone to infection,

644
00:15:45,666 --> 00:15:47,066
if they get little nicks.

645
00:15:47,066 --> 00:15:48,066
Wouldn't be able to get blood

646
00:15:48,066 --> 00:15:49,966
draws from that arm. Does it stay that way?

647
00:15:49,966 --> 00:15:51,000
Yes, it can.

648
00:15:51,000 --> 00:15:52,466
Some, some cases are permanent.

649
00:15:52,466 --> 00:15:55,166
Some cases will improve with time. Okay.

650
00:15:55,166 --> 00:15:57,866
And that, but it can be,

651
00:15:57,866 --> 00:15:59,866
you can decrease the risk for that.

652
00:15:59,866 --> 00:16:00,366
Number one,

653
00:16:00,366 --> 00:16:01,266
if you're doing a targeted

654
00:16:01,266 --> 00:16:02,266
axillary dissection

655
00:16:02,266 --> 00:16:03,666
and not doing a complete axillary

656
00:16:03,666 --> 00:16:03,966
dissection,

657
00:16:03,966 --> 00:16:05,400
that's the best thing you can do. Okay.

658
00:16:05,400 --> 00:16:06,266
But for patients

659
00:16:06,266 --> 00:16:08,366
who do need an axillary dissection here

660
00:16:08,366 --> 00:16:09,000
at UCI,

661
00:16:09,000 --> 00:16:11,000
we offer a lymphoid venous bypass.

662
00:16:11,000 --> 00:16:11,566
And that's

663
00:16:11,566 --> 00:16:13,266
where the plastic surgeon comes in.

664
00:16:13,266 --> 00:16:14,666
And they'll connect

665
00:16:14,666 --> 00:16:16,966
these lymphatic channels with the vein.

666
00:16:16,966 --> 00:16:18,566
And then that reduces that risk

667
00:16:18,566 --> 00:16:19,500
that you have of 20

668
00:16:19,500 --> 00:16:22,566
to 30% down to more like 5 to 10% back.

669
00:16:22,566 --> 00:16:22,800
Like it

670
00:16:22,800 --> 00:16:23,266
kind of brings

671
00:16:23,266 --> 00:16:25,666
you down to the risk of a sentinel biopsy.

672
00:16:25,666 --> 00:16:26,366
Oh, that's amazing. So it's huge

673
00:16:26,366 --> 00:16:28,966
and it's super great for patients

674
00:16:28,966 --> 00:16:30,000
because it can take

675
00:16:30,000 --> 00:16:30,966
what's one of the most

676
00:16:30,966 --> 00:16:34,666
feared complications of breast surgery

677
00:16:34,666 --> 00:16:36,366
in general and kind of make it

678
00:16:36,366 --> 00:16:38,966
almost negligible, which is awesome. Wow.

679
00:16:38,966 --> 00:16:40,166
But it's not offered everywhere.

680
00:16:40,166 --> 00:16:41,366
So it's one of the things where it's

681
00:16:41,366 --> 00:16:43,166
nice to be at an academic center

682
00:16:43,166 --> 00:16:45,166
where you have plastic surgeons

683
00:16:45,166 --> 00:16:46,666
who can, who can offer that.

684
00:16:46,666 --> 00:16:47,766
That's very good to know.

685
00:16:47,766 --> 00:16:49,400
So if somebody goes to their doctor

686
00:16:49,400 --> 00:16:50,366
and says, this is what I want,

687
00:16:50,366 --> 00:16:50,666
and they're like,

688
00:16:50,666 --> 00:16:51,600
we don't know what you're talking about,

689
00:16:51,600 --> 00:16:53,466
or we don't offer that, that's that

690
00:16:53,466 --> 00:16:55,966
this is not just universally done.

691
00:16:55,966 --> 00:16:57,366
Correct. Okay.

692
00:16:57,366 --> 00:16:58,766
That's, that's great to know.

693
00:16:58,766 --> 00:17:01,233
And during your training

694
00:17:01,233 --> 00:17:03,533
or maybe when you were a newer surgeon,

695
00:17:03,533 --> 00:17:05,533
were they like, okay, we got this thing.

696
00:17:05,533 --> 00:17:06,933
Like, is this something that you kind of

697
00:17:06,933 --> 00:17:09,133
had to learn about lifetime? Yes, I did.

698
00:17:09,133 --> 00:17:10,133
And so it was also

699
00:17:10,133 --> 00:17:11,033
another interesting thing.

700
00:17:11,033 --> 00:17:11,533
I remember

701
00:17:11,533 --> 00:17:12,833
at the beginning of my training,

702
00:17:12,833 --> 00:17:15,833
there had been, so I think it was

703
00:17:16,133 --> 00:17:18,366
in the 2010s, early 2010s,

704
00:17:18,366 --> 00:17:19,433
Z11 came out

705
00:17:19,433 --> 00:17:20,566
and that was a big deal

706
00:17:20,566 --> 00:17:21,966
for early-stage breast cancer.

707
00:17:21,966 --> 00:17:23,733
And it was all with lumpectomies

708
00:17:23,733 --> 00:17:24,533
and looking at

709
00:17:24,533 --> 00:17:25,833
whether or not those patients

710
00:17:25,833 --> 00:17:26,833
needed axillary dissection.

711
00:17:26,833 --> 00:17:28,233
So it was basically decreasing the,

712
00:17:28,233 --> 00:17:30,333
the need for that.

713
00:17:30,333 --> 00:17:33,033
But patients who had had mastectomies

714
00:17:33,033 --> 00:17:34,233
didn't fall into that.

715
00:17:34,233 --> 00:17:35,833
So what we were doing

716
00:17:35,833 --> 00:17:37,166
when I was first starting

717
00:17:37,166 --> 00:17:38,733
residency, was we were sending

718
00:17:38,733 --> 00:17:40,733
frozen sections of people's lymph nodes

719
00:17:40,733 --> 00:17:41,966
that were getting mastectomies,

720
00:17:41,966 --> 00:17:43,933
and if a lymph node was positive

721
00:17:43,933 --> 00:17:44,433
in the OR,

722
00:17:44,433 --> 00:17:45,833
you were doing the axillary dissection then.

723
00:17:45,833 --> 00:17:47,633
Then then we had AMAROS,

724
00:17:47,633 --> 00:17:48,966
which is with this other study

725
00:17:48,966 --> 00:17:51,033
that showed that these patients,

726
00:17:51,033 --> 00:17:52,766
as long as they had less than three

727
00:17:52,766 --> 00:17:53,766
lymph nodes that were positive,

728
00:17:53,766 --> 00:17:55,033
they didn't need a completion

729
00:17:55,033 --> 00:17:56,633
axillary dissection.

730
00:17:56,633 --> 00:17:58,933
And so we were able to expand

731
00:17:58,933 --> 00:18:00,033
the population

732
00:18:00,033 --> 00:18:01,333
that did not need

733
00:18:01,333 --> 00:18:03,233
extra surgery in their axilla.

734
00:18:03,233 --> 00:18:03,966
And that was just something

735
00:18:03,966 --> 00:18:05,533
that I saw in real time.

736
00:18:05,533 --> 00:18:07,066
And were you were,

737
00:18:07,066 --> 00:18:08,233
did you trust it right away

738
00:18:08,233 --> 00:18:09,033
or were you like,

739
00:18:09,033 --> 00:18:11,166
I don't know, we have our ways? Yeah.

740
00:18:11,166 --> 00:18:13,166
So I think everything takes a minute

741
00:18:13,166 --> 00:18:14,233
for people to get buy-in.

742
00:18:14,233 --> 00:18:14,833
And right now,

743
00:18:14,833 --> 00:18:15,933
the thing that we're kind of

744
00:18:15,933 --> 00:18:17,233
seeing slowly

745
00:18:17,233 --> 00:18:19,233
get the buy-in from practitioners

746
00:18:19,233 --> 00:18:20,233
is this whole idea

747
00:18:20,233 --> 00:18:20,833
that maybe you don't

748
00:18:20,833 --> 00:18:21,733
really need to sample

749
00:18:21,733 --> 00:18:23,333
the lymph nodes all the time. That is amazing.

750
00:18:23,333 --> 00:18:24,933
So it's a niche group, right?

751
00:18:24,933 --> 00:18:26,633
It's only these early-stage

752
00:18:26,633 --> 00:18:27,766
hormone-positive.

753
00:18:27,766 --> 00:18:29,066
Most people would not be comfortable

754
00:18:29,066 --> 00:18:31,233
offering it in premenopausal patients.

755
00:18:31,233 --> 00:18:33,333
So it's really the postmenopausal group.

756
00:18:33,333 --> 00:18:34,433
So and that's a,

757
00:18:34,433 --> 00:18:35,633
that's what I mean by it's

758
00:18:35,633 --> 00:18:37,833
so now. it's so bespoke

759
00:18:37,833 --> 00:18:38,433
as opposed to like

760
00:18:38,433 --> 00:18:39,533
let's just chop you in half

761
00:18:39,533 --> 00:18:41,033
and good luck to you. Exactly.

762
00:18:41,033 --> 00:18:42,833
Much more individualized.

763
00:18:42,833 --> 00:18:43,933
Well, we've talked about,

764
00:18:43,933 --> 00:18:44,833
you know, the procedures

765
00:18:44,833 --> 00:18:45,433
and the techniques.

766
00:18:45,433 --> 00:18:46,133
I'm wondering

767
00:18:46,133 --> 00:18:48,633
about the breast reconstruction for,

768
00:18:48,633 --> 00:18:50,366
you know, mastectomies and things like that.

769
00:18:50,366 --> 00:18:52,166
So when the tumor's removed,

770
00:18:53,333 --> 00:18:53,733
is it

771
00:18:53,733 --> 00:18:54,433
all done

772
00:18:54,433 --> 00:18:55,833
in one shot or do you come back

773
00:18:55,833 --> 00:18:57,533
later for that sort of thing?

774
00:18:57,533 --> 00:18:59,433
Usually we try to combine it

775
00:18:59,433 --> 00:19:01,133
with our plastic surgery. Okay.

776
00:19:01,133 --> 00:19:02,433
So our options are

777
00:19:02,433 --> 00:19:04,166
if you're going the lumpectomy route

778
00:19:04,166 --> 00:19:06,533
but you need a bigger lumpectomy,

779
00:19:06,533 --> 00:19:07,733
and so are, we,

780
00:19:07,733 --> 00:19:08,766
we can decide to do something

781
00:19:08,766 --> 00:19:10,433
called an oncoplastic reduction.

782
00:19:10,433 --> 00:19:12,433
So we're taking out, as the breast

783
00:19:12,433 --> 00:19:13,833
surgeon I'd be taking out the cancer.

784
00:19:13,833 --> 00:19:15,033
And then plastic surgery

785
00:19:15,033 --> 00:19:17,133
would come in during the same operation,

786
00:19:17,133 --> 00:19:18,433
rearrange the breast

787
00:19:18,433 --> 00:19:19,733
and kind of give you a smaller

788
00:19:19,733 --> 00:19:21,633
lifted breast. Okay.

789
00:19:21,633 --> 00:19:23,566
As you're all part of the one package.

790
00:19:23,566 --> 00:19:24,333
So it's nice

791
00:19:24,333 --> 00:19:25,733
because you're only in the OR

792
00:19:25,733 --> 00:19:26,433
that one time.

793
00:19:26,433 --> 00:19:27,233
Sometimes you may need

794
00:19:27,233 --> 00:19:28,333
to go back for adjustments

795
00:19:28,333 --> 00:19:29,433
or plastics down the road

796
00:19:29,433 --> 00:19:30,733
for cosmetic reasons,

797
00:19:30,733 --> 00:19:32,433
but it takes care of everything there.

798
00:19:32,433 --> 00:19:33,933
The other option is,

799
00:19:33,933 --> 00:19:35,733
if you're doing a full mastectomy,

800
00:19:35,733 --> 00:19:36,833
we try to have plastics there

801
00:19:36,833 --> 00:19:39,166
at the same time for the recon then, too.

802
00:19:39,166 --> 00:19:40,966
And so they'll put in,

803
00:19:40,966 --> 00:19:42,633
they can either do direct to implant,

804
00:19:42,633 --> 00:19:43,933
but more often than not

805
00:19:43,933 --> 00:19:44,833
they're putting something called

806
00:19:44,833 --> 00:19:46,433
tissue expanders in place. Okay.

807
00:19:46,433 --> 00:19:46,733
That's what

808
00:19:46,733 --> 00:19:48,166
I was just going to ask about.

809
00:19:48,166 --> 00:19:49,766
Yes, I have a couple friends

810
00:19:49,766 --> 00:19:50,633
who have that.

811
00:19:50,633 --> 00:19:51,666
Who've done tissue expanders?

812
00:19:51,666 --> 00:19:51,966
Yes.

813
00:19:51,966 --> 00:19:54,566
Actually, three or four. Wow.

814
00:19:54,566 --> 00:19:56,933
And they were in for a while,

815
00:19:56,933 --> 00:19:58,433
and that's just to stretch the skin,

816
00:19:58,433 --> 00:19:59,066
I imagine.

817
00:19:59,066 --> 00:19:59,933
Yeah. Yep.

818
00:19:59,933 --> 00:20:00,833
So what we do

819
00:20:00,833 --> 00:20:01,966
is we combine this with a skin-

820
00:20:01,966 --> 00:20:03,833
sparing mastectomy, so...

821
00:20:03,833 --> 00:20:04,966
Or a nipple-sparing

822
00:20:04,966 --> 00:20:06,333
mastectomy, depending on,

823
00:20:06,333 --> 00:20:07,233
you know, we can...

824
00:20:07,233 --> 00:20:08,733
There's a group of patients

825
00:20:08,733 --> 00:20:10,433
who would qualify for nipple sparing.

826
00:20:10,433 --> 00:20:12,233
If you've got smaller breasts,

827
00:20:12,233 --> 00:20:13,766
not a lot of nipple ptosis,

828
00:20:13,766 --> 00:20:14,566
depending on also

829
00:20:14,566 --> 00:20:16,133
where the tumor is in relation

830
00:20:16,133 --> 00:20:17,733
to the nipple areola complex.

831
00:20:17,733 --> 00:20:19,633
We could maybe offer nipple sparing,

832
00:20:19,633 --> 00:20:20,533
but if not,

833
00:20:20,533 --> 00:20:22,233
then you could get a skin-sparing mastectomy.

834
00:20:22,233 --> 00:20:23,333
So we remove the nipple,

835
00:20:23,333 --> 00:20:25,633
but we retain the majority of the skin

836
00:20:25,633 --> 00:20:26,633
of the breast. Got it.

837
00:20:26,633 --> 00:20:28,233
So then the breast surgeon

838
00:20:28,233 --> 00:20:30,433
comes in, removes all of the tissue.

839
00:20:30,433 --> 00:20:32,333
Plastic surgery comes, in places

840
00:20:32,333 --> 00:20:33,766
the tissue expander in.

841
00:20:33,766 --> 00:20:34,533
And what that is,

842
00:20:34,533 --> 00:20:36,333
is it's kind of a placeholder.

843
00:20:36,333 --> 00:20:37,233
So you'll look...

844
00:20:37,233 --> 00:20:39,766
Yeah. Semi-flat at the beginning of,

845
00:20:39,766 --> 00:20:40,933
right after your surgery.

846
00:20:40,933 --> 00:20:42,233
And then over the subsequent weeks

847
00:20:42,233 --> 00:20:43,533
they'll inject saline.

848
00:20:43,533 --> 00:20:44,833
They'll kind of stretch it

849
00:20:44,833 --> 00:20:46,733
and it helps stretch the remaining skin

850
00:20:46,733 --> 00:20:48,033
which we've left most of it.

851
00:20:48,033 --> 00:20:49,433
But you've lost some.

852
00:20:49,433 --> 00:20:50,833
And so then it stretches it and helps

853
00:20:50,833 --> 00:20:52,633
you get to the size you ultimately want.

854
00:20:52,633 --> 00:20:55,633
And then down the road you plan for your,

855
00:20:55,933 --> 00:20:57,133
your permanent implant

856
00:20:57,133 --> 00:20:59,933
to be placed. Right. God, that's so cool.

857
00:20:59,933 --> 00:21:00,566
Because, you know,

858
00:21:00,566 --> 00:21:01,766
you think

859
00:21:01,766 --> 00:21:02,966
I would imagine before

860
00:21:02,966 --> 00:21:04,333
this was an option like,

861
00:21:04,333 --> 00:21:04,933
well, you know,

862
00:21:04,933 --> 00:21:06,033
and, and truly like, well,

863
00:21:06,033 --> 00:21:07,533
I'm just lucky to be alive. Yes.

864
00:21:07,533 --> 00:21:08,366
But you now

865
00:21:08,366 --> 00:21:09,966
you have the rest of your life to live

866
00:21:09,966 --> 00:21:12,333
and your your body feels unfamiliar

867
00:21:12,333 --> 00:21:13,133
and you don't...

868
00:21:13,133 --> 00:21:14,366
It doesn't look

869
00:21:14,366 --> 00:21:15,233
and feel like what

870
00:21:15,233 --> 00:21:16,333
you want it to look and feel like.

871
00:21:16,333 --> 00:21:19,333
So the fact that that doctors take

872
00:21:19,366 --> 00:21:21,833
the reconstruction seriously

873
00:21:21,833 --> 00:21:23,533
is really, really nice.

874
00:21:23,533 --> 00:21:24,533
And I'm sure it just

875
00:21:24,533 --> 00:21:26,133
it makes all the difference in the world

876
00:21:26,133 --> 00:21:26,933
for patients.

877
00:21:26,933 --> 00:21:27,733
Oh, absolutely.

878
00:21:27,733 --> 00:21:28,566
It's a huge...

879
00:21:28,566 --> 00:21:29,433
because it's just,

880
00:21:29,433 --> 00:21:32,133
it's not appropriate to say,

881
00:21:32,133 --> 00:21:33,733
okay, we've cured you of your cancer,

882
00:21:33,733 --> 00:21:36,733
now go live another 50 years,

883
00:21:36,733 --> 00:21:37,733
not liking

884
00:21:37,733 --> 00:21:38,933
what you're seeing in the mirror.

885
00:21:38,933 --> 00:21:40,566
Like this is already a horrible ordeal
,

886
00:21:40,566 --> 00:21:42,333
to have to go through a baseline to

887
00:21:42,333 --> 00:21:42,766
then say,

888
00:21:42,766 --> 00:21:43,566
oh, and you're going to have to

889
00:21:43,566 --> 00:21:44,933
constantly be reminded of it.

890
00:21:44,933 --> 00:21:45,233
Yeah.

891
00:21:45,233 --> 00:21:45,966
So I mean, it's

892
00:21:45,966 --> 00:21:47,166
never going to be perfect, right?

893
00:21:47,166 --> 00:21:47,933
We're not...

894
00:21:47,933 --> 00:21:50,533
Yeah. But you will feel put back together.

895
00:21:50,533 --> 00:21:51,633
You won't feel like you were left

896
00:21:51,633 --> 00:21:52,633
in that state.

897
00:21:52,633 --> 00:21:54,633
I actually saw a video

898
00:21:54,633 --> 00:21:55,633
not too long ago

899
00:21:55,633 --> 00:21:58,733
of plastic surgeons and tattoo artists

900
00:21:58,733 --> 00:21:59,833
that do these really amazing,

901
00:21:59,833 --> 00:22:01,733
like, three dimensional nipples.

902
00:22:01,733 --> 00:22:02,933
Oh, my gosh, I love this so much.

903
00:22:02,933 --> 00:22:04,833
And I always show my patients... The best!

904
00:22:04,833 --> 00:22:06,333
Yes, I always show patients

905
00:22:06,333 --> 00:22:07,233
who aren't good candidates

906
00:22:07,233 --> 00:22:08,433
for things like nipple sparing,

907
00:22:08,433 --> 00:22:09,566
but they're really concerned

908
00:22:09,566 --> 00:22:10,566
about losing that

909
00:22:10,566 --> 00:22:11,833
because it's such an integral part

910
00:22:11,833 --> 00:22:13,933
of being a woman. Right?

911
00:22:13,933 --> 00:22:14,933
So I showed it to them

912
00:22:14,933 --> 00:22:16,366
and it is so amazing.

913
00:22:16,366 --> 00:22:16,933
It's amazing.

914
00:22:16,933 --> 00:22:18,333
You can't tell the difference... Nope.

915
00:22:18,333 --> 00:22:20,166
And you know it.

916
00:22:20,166 --> 00:22:21,533
I think it is a huge comfort

917
00:22:21,533 --> 00:22:22,433
to a lot of people to know

918
00:22:22,433 --> 00:22:23,733
that you have this option

919
00:22:23,733 --> 00:22:26,333
to look and feel normal again.

920
00:22:26,333 --> 00:22:27,166
And it's, you know,

921
00:22:27,166 --> 00:22:29,733
I also know someone who had the option.

922
00:22:29,733 --> 00:22:30,033
She's like,

923
00:22:30,033 --> 00:22:31,733
I wanted a tattoo of a flower.

924
00:22:31,733 --> 00:22:33,933
I'm like, you do your thing, girl.

925
00:22:33,933 --> 00:22:36,933
But the, the realisticness of some of these tattoos is unbelievable.

926
00:22:37,533 --> 00:22:39,033
They are true artists.

927
00:22:39,033 --> 00:22:40,533
I agree.

928
00:22:40,533 --> 00:22:41,333
Oh my god.

929
00:22:41,333 --> 00:22:44,333
And I had breast reduction surgery

930
00:22:44,433 --> 00:22:47,233
and I had wanted to do it for

931
00:22:47,233 --> 00:22:49,333
two decades. But I was scared then.

932
00:22:49,333 --> 00:22:49,733
And you know,

933
00:22:49,733 --> 00:22:50,833
you hear these horror stories.

934
00:22:50,833 --> 00:22:52,633
And now we got into like,

935
00:22:52,633 --> 00:22:54,433
you know, the 2020s.

936
00:22:54,433 --> 00:22:55,566
And I was like, oh, okay.

937
00:22:55,566 --> 00:22:58,133
And I just kind of casually see. I think I'm ready. Yeah.

938
00:22:58,133 --> 00:22:58,933
And seeing how,

939
00:22:58,933 --> 00:22:59,633
how the,

940
00:22:59,633 --> 00:23:00,833
the options had changed

941
00:23:00,833 --> 00:23:01,733
and sort of evolved

942
00:23:01,733 --> 00:23:03,766
and I, I'm so glad

943
00:23:03,766 --> 00:23:05,366
I waited just because for me

944
00:23:05,366 --> 00:23:06,366
it was the right thing to do.

945
00:23:06,366 --> 00:23:07,933
And I liked seeing,

946
00:23:07,933 --> 00:23:10,033
you know, how the technology had evolved.

947
00:23:10,033 --> 00:23:11,033
So, yeah,

948
00:23:11,033 --> 00:23:13,433
I mean, I trust me, I'm on board.

949
00:23:13,433 --> 00:23:14,033
Knock me out,

950
00:23:14,033 --> 00:23:16,433
wake me up, give me a smaller size.

951
00:23:16,433 --> 00:23:17,433
We're in a good place.

952
00:23:18,633 --> 00:23:19,166
Yeah.

953
00:23:19,166 --> 00:23:19,933
So.

954
00:23:19,933 --> 00:23:20,966
But you know,

955
00:23:20,966 --> 00:23:22,033
we talked about a little bit,

956
00:23:22,033 --> 00:23:24,733
but in terms of other options

957
00:23:24,733 --> 00:23:26,133
besides implants,

958
00:23:26,133 --> 00:23:27,733
does anyone ever just say,

959
00:23:27,733 --> 00:23:27,966
you know,

960
00:23:27,966 --> 00:23:29,333
I'd rather just not keep going

961
00:23:29,333 --> 00:23:31,633
through these surgeries? I'm, I'm good.

962
00:23:31,633 --> 00:23:32,766
Yeah. We, absolutely.

963
00:23:32,766 --> 00:23:35,433
We can have an aesthetic flat closure.

964
00:23:35,433 --> 00:23:36,333
And that's an option

965
00:23:36,333 --> 00:23:37,633
if somebody, you know,

966
00:23:37,633 --> 00:23:39,733
needs, wants a mastectomy

967
00:23:39,733 --> 00:23:41,233
and they don't want any reconstruction,

968
00:23:41,233 --> 00:23:42,633
you can just go flat.

969
00:23:42,633 --> 00:23:45,633
And that, there's a whole group of of,

970
00:23:45,833 --> 00:23:46,533
you know, patients

971
00:23:46,533 --> 00:23:47,966
and survivors of breast cancer

972
00:23:47,966 --> 00:23:50,633
who really rally behind that and,

973
00:23:50,633 --> 00:23:51,533
you know,

974
00:23:51,533 --> 00:23:54,033
empower each other with... I love it. With that choice

975
00:23:54,033 --> 00:23:55,366
because it's awesome, too.

976
00:23:55,366 --> 00:23:56,033
And that's the thing.

977
00:23:56,033 --> 00:23:56,233
I mean,

978
00:23:56,233 --> 00:23:57,166
I would just imagine

979
00:23:57,166 --> 00:23:58,833
just depending on your tolerance

980
00:23:58,833 --> 00:24:00,033
and mine's very low,

981
00:24:00,033 --> 00:24:03,433
but just going through this process and,

982
00:24:03,533 --> 00:24:03,933
you know,

983
00:24:03,933 --> 00:24:05,533
whether you do chemo or radiation

984
00:24:05,533 --> 00:24:06,733
and the surgeries, it'd be like,

985
00:24:06,733 --> 00:24:07,433
you know what?

986
00:24:07,433 --> 00:24:08,433
I'm going to choose

987
00:24:08,433 --> 00:24:10,566
as, as few surgeries as possible.

988
00:24:10,566 --> 00:24:11,333
And when we're done

989
00:24:11,333 --> 00:24:12,733
here, we're done here. Yeah.

990
00:24:12,733 --> 00:24:14,766
So I absolutely understand that.

991
00:24:14,766 --> 00:24:16,333
So what is the recovery

992
00:24:16,333 --> 00:24:18,833
like for a breast surgery?

993
00:24:18,833 --> 00:24:20,533
Depends on the surgery that you do.

994
00:24:20,533 --> 00:24:22,633
So I always counsel patients

995
00:24:22,633 --> 00:24:26,333
a lumpectomy, shorter surgery, ambulatory.

996
00:24:26,366 --> 00:24:28,233
You go home the same day. Oh you do?

997
00:24:28,233 --> 00:24:28,633
Yes.

998
00:24:28,633 --> 00:24:31,633
And quicker recovery, less pain.

999
00:24:32,333 --> 00:24:33,133
For sure.

1000
00:24:33,133 --> 00:24:34,133
So I usually tell them

1001
00:24:34,133 --> 00:24:35,133
about one to two weeks,

1002
00:24:35,133 --> 00:24:37,333
but most patients will feel pretty good

1003
00:24:37,333 --> 00:24:38,833
within the first few days.

1004
00:24:38,833 --> 00:24:39,933
You'll be a little bit sore.

1005
00:24:39,933 --> 00:24:40,766
I always send patients

1006
00:24:40,766 --> 00:24:41,933
home with pain medication,

1007
00:24:41,933 --> 00:24:42,766
usually a combination

1008
00:24:42,766 --> 00:24:44,166
of Tylenol, ibuprofen,

1009
00:24:44,166 --> 00:24:45,566
and then depending on how much we do,

1010
00:24:45,566 --> 00:24:47,033
maybe something a little bit stronger.

1011
00:24:47,033 --> 00:24:49,133
Do you use a nerve blocker?

1012
00:24:49,133 --> 00:24:51,233
I will give, I'll give local

1013
00:24:51,233 --> 00:24:52,033
and sometimes local

1014
00:24:52,033 --> 00:24:53,233
directly into the muscle

1015
00:24:53,233 --> 00:24:55,133
that will kind of serve as a nerve blocker. Okay

1016
00:24:55,133 --> 00:24:56,366
And sometimes we'll have anesthesia as well. 

1017
00:24:56,366 --> 00:24:57,833
I had surgery and was, like, this really wasn't bad.

1018
00:24:57,833 --> 00:24:59,833
She's, like, ice took care of that. Yeah.

1019
00:24:59,833 --> 00:25:01,866
Yes, yes, yes, yes. Absolutely.

1020
00:25:01,866 --> 00:25:03,300
So besides what you do,

1021
00:25:03,300 --> 00:25:04,500
which is a miracle

1022
00:25:04,500 --> 00:25:05,666
and we thank you for it...

1023
00:25:05,666 --> 00:25:06,966
And I, you know

1024
00:25:06,966 --> 00:25:07,766
plastic surgeon

1025
00:25:07,766 --> 00:25:09,566
what other specialists are sort of

1026
00:25:09,566 --> 00:25:11,300
part of that breast cancer team

1027
00:25:11,300 --> 00:25:12,566
at UCI Health. Yeah.

1028
00:25:12,566 --> 00:25:14,966
So when when somebody walks in the door

1029
00:25:14,966 --> 00:25:16,366
with a new breast cancer diagnosis,

1030
00:25:16,366 --> 00:25:17,966
you know, I'll explain to them

1031
00:25:17,966 --> 00:25:20,266
this is a multidisciplinary approach.

1032
00:25:20,266 --> 00:25:21,866
We have a multidisciplinary approach.

1033
00:25:21,866 --> 00:25:23,700
So not only do you see a breast surgeon,

1034
00:25:23,700 --> 00:25:25,100
you see a breast

1035
00:25:25,100 --> 00:25:26,300
radiologist who's doing

1036
00:25:26,300 --> 00:25:27,466
your mammograms,

1037
00:25:27,466 --> 00:25:28,166
who's often calling you

1038
00:25:28,166 --> 00:25:29,466
with the results of those.

1039
00:25:29,466 --> 00:25:31,466
We also have medical oncologists

1040
00:25:31,466 --> 00:25:32,366
because they're the ones

1041
00:25:32,366 --> 00:25:32,866
who are going to be

1042
00:25:32,866 --> 00:25:34,266
deciding about the chemo.

1043
00:25:34,266 --> 00:25:35,266
They're the ones that are going to be

1044
00:25:35,266 --> 00:25:36,700
maybe giving you the endocrine therapy

1045
00:25:36,700 --> 00:25:38,166
if you qualify for that.

1046
00:25:38,166 --> 00:25:39,266
And we have a radiation

1047
00:25:39,266 --> 00:25:40,466
oncologist as well,

1048
00:25:40,466 --> 00:25:40,766
and they're

1049
00:25:40,766 --> 00:25:40,966
the ones

1050
00:25:40,966 --> 00:25:42,966
that would be offering radiation.

1051
00:25:42,966 --> 00:25:44,300
So if you had a lumpectomy

1052
00:25:44,300 --> 00:25:46,466
and you needed radiation adjuvantly

1053
00:25:46,466 --> 00:25:47,666
after your surgery,

1054
00:25:47,666 --> 00:25:49,566
radiation oncology is who does that.

1055
00:25:49,566 --> 00:25:50,300
So it's a big...

1056
00:25:50,300 --> 00:25:50,700
and of course

1057
00:25:50,700 --> 00:25:51,666
our breast pathologists

1058
00:25:51,666 --> 00:25:52,066
because they're

1059
00:25:52,066 --> 00:25:53,266
the ones that are telling us, okay,

1060
00:25:53,266 --> 00:25:54,866
this is the type of breast cancer it is,

1061
00:25:54,866 --> 00:25:55,866
these are the receptors

1062
00:25:55,866 --> 00:25:56,900
that are involved.

1063
00:25:56,900 --> 00:25:58,300
And so it's a big, big group.

1064
00:25:58,300 --> 00:26:00,066
And we have meetings and tumor boards

1065
00:26:00,066 --> 00:26:01,900
all the time to discuss these patients

1066
00:26:01,900 --> 00:26:03,366
to make sure that everybody's on board.

1067
00:26:03,366 --> 00:26:05,266
And we have a plan that's personalized.

1068
00:26:05,266 --> 00:26:06,466
And... That's amazing. You know

1069
00:26:06,466 --> 00:26:07,466
good to get that patient

1070
00:26:07,466 --> 00:26:08,066
to the next step.

1071
00:26:08,066 --> 00:26:09,100
I always wondered about that.

1072
00:26:09,100 --> 00:26:09,666
Like you see on

1073
00:26:09,666 --> 00:26:10,266
medical shows,

1074
00:26:10,266 --> 00:26:11,466
all of these doctors

1075
00:26:11,466 --> 00:26:12,266
getting together

1076
00:26:12,266 --> 00:26:13,766
and talking about a patient. I'd be like,

1077
00:26:13,766 --> 00:26:14,366
if that was me,

1078
00:26:14,366 --> 00:26:15,500
they would just be talking about

1079
00:26:15,500 --> 00:26:16,866
little me and debating.

1080
00:26:16,866 --> 00:26:18,666
And I mean like that... You really do that.

1081
00:26:18,666 --> 00:26:19,266
We do.

1082
00:26:19,266 --> 00:26:20,300
That is who we do.

1083
00:26:20,300 --> 00:26:20,966
Because, you know,

1084
00:26:20,966 --> 00:26:21,566
we want to make sure

1085
00:26:21,566 --> 00:26:23,166
that we're doing the best thing

1086
00:26:23,166 --> 00:26:23,900
for that patient.

1087
00:26:23,900 --> 00:26:24,966
And so

1088
00:26:24,966 --> 00:26:27,766
really having more sets of eyes and,

1089
00:26:27,766 --> 00:26:27,966
you know,

1090
00:26:27,966 --> 00:26:30,566
more opinions and looking at the data

1091
00:26:30,566 --> 00:26:31,700
and talking about that data

1092
00:26:31,700 --> 00:26:33,366
and how it applies to that person,

1093
00:26:33,366 --> 00:26:34,966
that's what's going to get this person

1094
00:26:34,966 --> 00:26:35,566
through this.

1095
00:26:35,566 --> 00:26:36,466
And, you know,

1096
00:26:36,466 --> 00:26:37,900
give them the extra 50 years.

1097
00:26:37,900 --> 00:26:38,766
That's incredible.

1098
00:26:38,766 --> 00:26:39,666
Do you ever feel like

1099
00:26:39,666 --> 00:26:41,266
you really have to dig your...

1100
00:26:41,266 --> 00:26:42,166
Has there been experience

1101
00:26:42,166 --> 00:26:43,866
where you had to really dig your heels in

1102
00:26:43,866 --> 00:26:45,500
and just really disagree with somebody

1103
00:26:45,500 --> 00:26:48,066
during this conversation?

1104
00:26:48,066 --> 00:26:49,066
You know, a few times

1105
00:26:49,066 --> 00:26:50,066
there's some disagreements.

1106
00:26:50,066 --> 00:26:50,766
Like everybody,

1107
00:26:50,766 --> 00:26:52,466
you know, might have their,

1108
00:26:52,466 --> 00:26:54,300
their particular anecdotal things,

1109
00:26:54,300 --> 00:26:55,266
but at the end of the day, it's

1110
00:26:55,266 --> 00:26:56,266
like we're going by data

1111
00:26:56,266 --> 00:26:57,766
and going by what we've got.

1112
00:26:57,766 --> 00:26:59,500
Most of the time, we'll have an agreement.

1113
00:26:59,500 --> 00:27:00,366
And.. Doctor House

1114
00:27:00,366 --> 00:27:01,766
doesn't just like throw his cane

1115
00:27:01,766 --> 00:27:02,866
and walk out of the room.

1116
00:27:02,866 --> 00:27:03,966
It's not like that.

1117
00:27:03,966 --> 00:27:04,966
No, no,

1118
00:27:04,966 --> 00:27:05,900
not, not, not

1119
00:27:05,900 --> 00:27:07,666
nearly that dramatic. Okay, I've watched a lot of medical drama.

1120
00:27:07,666 --> 00:27:09,966
So I just want to see if that's real. Oh, girl, me too.

1121
00:27:09,966 --> 00:27:11,566
Obsessed with The Pitt, by the way.

1122
00:27:11,566 --> 00:27:13,466
Oh, it is so good. So good.

1123
00:27:13,466 --> 00:27:14,500
That's a really good show.

1124
00:27:14,500 --> 00:27:17,100
And, and actually pretty accurate.

1125
00:27:17,100 --> 00:27:18,966
That's what everybody says – like

1126
00:27:18,966 --> 00:27:20,666
out of all of the medical dramas,

1127
00:27:20,666 --> 00:27:23,166
like, they got a lot right apparently.

1128
00:27:23,166 --> 00:27:24,066
Yeah, yeah, I kind of...

1129
00:27:24,066 --> 00:27:24,766
I was very sad

1130
00:27:24,766 --> 00:27:25,866
with the way they portrayed

1131
00:27:25,866 --> 00:27:27,266
the surgical resident in it

1132
00:27:27,266 --> 00:27:27,900
at the beginning.

1133
00:27:27,900 --> 00:27:29,866
Oh, she came off as kind of harsh.

1134
00:27:29,866 --> 00:27:30,366
Yeah.

1135
00:27:30,366 --> 00:27:32,366
But, but overall...

1136
00:27:32,366 --> 00:27:32,666
You know,

1137
00:27:32,666 --> 00:27:33,300
let's sprinkle

1138
00:27:33,300 --> 00:27:34,666
in some medical professionals

1139
00:27:34,666 --> 00:27:35,966
with personality disorders.

1140
00:27:35,966 --> 00:27:37,466
Yes. Just to spice things up. Yes.

1141
00:27:37,466 --> 00:27:38,566
I mean, not to say they're not,

1142
00:27:38,566 --> 00:27:40,700
that's not the truth. Right?

1143
00:27:42,066 --> 00:27:42,466
But, you know,

1144
00:27:42,466 --> 00:27:43,100
there's no need to

1145
00:27:43,100 --> 00:27:46,100
broadcast all the pathologic natures to the world.

1146
00:27:46,266 --> 00:27:47,366
We don't need to look that far

1147
00:27:47,366 --> 00:27:49,066
behind the curtain.

1148
00:27:49,066 --> 00:27:49,666
Exactly.

1149
00:27:49,666 --> 00:27:50,866
Well, I love that

1150
00:27:50,866 --> 00:27:52,700
there's all these awesome advancements.

1151
00:27:52,700 --> 00:27:53,466
And I'm wondering

1152
00:27:53,466 --> 00:27:54,566
if you know of anything

1153
00:27:54,566 --> 00:27:55,966
that's sort of on the horizon

1154
00:27:55,966 --> 00:27:57,666
that maybe isn't ready yet,

1155
00:27:57,666 --> 00:27:58,700
but you're hearing

1156
00:27:58,700 --> 00:27:59,466
sort of whispers

1157
00:27:59,466 --> 00:28:01,666
about the next level of care for...

1158
00:28:01,666 --> 00:28:02,966
Yeah. Breast cancer.

1159
00:28:02,966 --> 00:28:05,100
So, so again,

1160
00:28:05,100 --> 00:28:06,766
we're really just ahead of every,

1161
00:28:06,766 --> 00:28:09,666
I think, other oncology

1162
00:28:09,666 --> 00:28:10,966
team in what we're doing.

1163
00:28:10,966 --> 00:28:11,766
And so one of the things,

1164
00:28:11,766 --> 00:28:13,100
and it's already here,

1165
00:28:13,100 --> 00:28:14,100
but it's just kind of slowly

1166
00:28:14,100 --> 00:28:15,100
being rolled out to places...

1167
00:28:15,100 --> 00:28:17,066
But the robotic mastectomy has been now

1168
00:28:17,066 --> 00:28:18,466
FDA approved. Really.

1169
00:28:18,466 --> 00:28:18,966
And so

1170
00:28:18,966 --> 00:28:20,566
I think you're going to be hearing

1171
00:28:20,566 --> 00:28:21,666
and seeing more of that

1172
00:28:21,666 --> 00:28:22,766
in the next few years

1173
00:28:22,766 --> 00:28:23,466
as people,

1174
00:28:23,466 --> 00:28:24,166
as the surgeons

1175
00:28:24,166 --> 00:28:26,566
get trained in how to do it.

1176
00:28:26,566 --> 00:28:28,300
So I think a lot of younger surgeons,

1177
00:28:28,300 --> 00:28:28,866
like, for example,

1178
00:28:28,866 --> 00:28:30,066
when I was in my training,

1179
00:28:30,066 --> 00:28:31,766
I got robotic training. You did?

1180
00:28:31,766 --> 00:28:33,500
But people who are a little bit,

1181
00:28:33,500 --> 00:28:34,900
you know, further in their careers,

1182
00:28:34,900 --> 00:28:36,366
they may have not had robotic training.

1183
00:28:36,366 --> 00:28:38,700
So as we roll it out, it's going to be

1184
00:28:38,700 --> 00:28:39,866
it's going to be a really great thing

1185
00:28:39,866 --> 00:28:40,900
to offer to patients because smaller incisions.

1186
00:28:42,366 --> 00:28:43,766
How do you feel about it? I'm really excited about it.

1187
00:28:43,766 --> 00:28:45,700
I think. So ergonomically it'll be great.

1188
00:28:45,700 --> 00:28:45,900
You know,

1189
00:28:45,900 --> 00:28:46,766
especially for nipple,

1190
00:28:46,766 --> 00:28:47,900
nipple-sparing mastectomies.

1191
00:28:47,900 --> 00:28:49,066
It's, it's really

1192
00:28:49,066 --> 00:28:50,566
it'll, it'll be a really nice thing

1193
00:28:50,566 --> 00:28:51,866
because the incisions

1194
00:28:51,866 --> 00:28:53,066
will be even smaller.

1195
00:28:53,066 --> 00:28:53,866
A lot of times

1196
00:28:53,866 --> 00:28:55,666
they're hidden in the side.

1197
00:28:55,666 --> 00:28:56,700
Now, a lot of the times

1198
00:28:56,700 --> 00:28:57,466
we're able to do inframammary

1199
00:28:57,466 --> 00:28:59,366
nipple-sparing mastectomies,

1200
00:28:59,366 --> 00:29:01,166
but with the robot, it can be,

1201
00:29:01,166 --> 00:29:01,366
you know,

1202
00:29:01,366 --> 00:29:02,700
a smaller incision and on the side.

1203
00:29:02,700 --> 00:29:04,500
So even better hidden.

1204
00:29:04,500 --> 00:29:06,166
And if you can have similar outcomes,

1205
00:29:06,166 --> 00:29:08,166
which with FDA approval, we've proven

1206
00:29:08,166 --> 00:29:09,300
we can. Why,

1207
00:29:09,300 --> 00:29:09,766
why not?

1208
00:29:09,766 --> 00:29:11,366
Why not push the envelope further?

1209
00:29:11,366 --> 00:29:14,166
So that's exciting. We also have

1210
00:29:14,166 --> 00:29:16,566
this, the LumiSystem has now come out

1211
00:29:16,566 --> 00:29:19,166
where we're looking at being able to

1212
00:29:19,166 --> 00:29:21,566
see margins in real time...

1213
00:29:21,566 --> 00:29:23,866
Really? By having cancer cells light up.

1214
00:29:23,866 --> 00:29:25,300
And so I think we're going to be seeing

1215
00:29:25,300 --> 00:29:26,966
that being used intraoperatively

1216
00:29:26,966 --> 00:29:28,100
to decrease chances

1217
00:29:28,100 --> 00:29:29,166
for lumpectomy patients

1218
00:29:29,166 --> 00:29:29,700
that they end up

1219
00:29:29,700 --> 00:29:30,900
having more positive margins

1220
00:29:30,900 --> 00:29:32,366
that require going back.

1221
00:29:32,366 --> 00:29:33,700
So I think

1222
00:29:33,700 --> 00:29:34,566
we're going to be seeing

1223
00:29:34,566 --> 00:29:35,666
even more advancements

1224
00:29:35,666 --> 00:29:36,666
that really change the game

1225
00:29:36,666 --> 00:29:37,566
for breast cancer patients.

1226
00:29:37,566 --> 00:29:39,166
I mean, I'm hoping

1227
00:29:39,166 --> 00:29:41,566
that in my lifetime we'll find,

1228
00:29:41,566 --> 00:29:41,966
you know,

1229
00:29:41,966 --> 00:29:43,966
maybe axillary surgery becomes

1230
00:29:43,966 --> 00:29:45,166
almost obsolete

1231
00:29:45,166 --> 00:29:48,366
or just as a prognostic marker

1232
00:29:48,466 --> 00:29:49,666
where you're just sampling nodes

1233
00:29:49,666 --> 00:29:50,966
just to see how the patient's

1234
00:29:50,966 --> 00:29:51,866
going to do with this

1235
00:29:51,866 --> 00:29:53,700
very specific treatment.

1236
00:29:53,700 --> 00:29:54,966
And maybe with really,

1237
00:29:54,966 --> 00:29:55,766
really good treatments,

1238
00:29:55,766 --> 00:29:57,266
we won't even need breast surgery.

1239
00:29:57,266 --> 00:29:58,500
I mean, we may get there.

1240
00:29:58,500 --> 00:29:59,866
I think it'll be a while.

1241
00:29:59,866 --> 00:30:00,100
Sure.

1242
00:30:00,100 --> 00:30:01,866
But, we're making a lot of progress. But you can see

1243
00:30:01,866 --> 00:30:03,166
the way things are going and...

1244
00:30:03,166 --> 00:30:04,166
Yeah, it's, it's

1245
00:30:04,166 --> 00:30:06,566
definitely going... Just in last 50 years

1246
00:30:06,566 --> 00:30:08,366
it's been a complete 180.

1247
00:30:08,366 --> 00:30:10,366
And how we first approached

1248
00:30:10,366 --> 00:30:11,300
breast cancer.

1249
00:30:11,300 --> 00:30:12,066
In addition

1250
00:30:12,066 --> 00:30:14,166
to the multidisciplinary aspect

1251
00:30:14,166 --> 00:30:15,700
and the tumor boards that we have,

1252
00:30:15,700 --> 00:30:16,466
we also

1253
00:30:16,466 --> 00:30:17,600
here at UCI

1254
00:30:17,600 --> 00:30:18,966
offer this amazing thing

1255
00:30:18,966 --> 00:30:20,566
called integrative oncology.

1256
00:30:20,566 --> 00:30:21,600
And this is where we're kind of looking

1257
00:30:21,600 --> 00:30:23,700
at the patient from a holistic manner,

1258
00:30:23,700 --> 00:30:25,500
not just looking at what treatments

1259
00:30:25,500 --> 00:30:26,866
they're receiving from the outside,

1260
00:30:26,866 --> 00:30:28,566
but also other things that they can do

1261
00:30:28,566 --> 00:30:29,700
to improve outcomes, to

1262
00:30:29,700 --> 00:30:32,300
change the ecosystem of the patient.

1263
00:30:32,300 --> 00:30:32,600
You know,

1264
00:30:32,600 --> 00:30:33,900
looking at diet changes,

1265
00:30:33,900 --> 00:30:35,466
looking at exercise changes

1266
00:30:35,466 --> 00:30:36,900
that they can make,

1267
00:30:36,900 --> 00:30:38,766
acupuncture, meditation,

1268
00:30:38,766 --> 00:30:39,966
things like yoga.

1269
00:30:39,966 --> 00:30:40,366
And it's

1270
00:30:40,366 --> 00:30:42,566
this really amazing approach

1271
00:30:42,566 --> 00:30:44,166
of, to the patient

1272
00:30:44,166 --> 00:30:46,300
to change the environment

1273
00:30:46,300 --> 00:30:47,566
that the cancer is working in.

1274
00:30:47,566 --> 00:30:48,566
And we've seen and we're

1275
00:30:48,566 --> 00:30:49,966
running clinical trials now

1276
00:30:49,966 --> 00:30:51,900
to show that there are improvements

1277
00:30:51,900 --> 00:30:52,900
in outcomes in patients

1278
00:30:52,900 --> 00:30:53,900
who are also using

1279
00:30:53,900 --> 00:30:55,300
this other intervention.

1280
00:30:55,300 --> 00:30:56,266
So it's really exciting

1281
00:30:56,266 --> 00:30:57,266
that we can offer that here

1282
00:30:57,266 --> 00:30:58,566
with Doctor Dang running it.

1283
00:30:58,566 --> 00:30:59,266
That's amazing

1284
00:30:59,266 --> 00:31:00,566
because you think, you know,

1285
00:31:00,566 --> 00:31:03,166
so many people are so jaded –– like, well,

1286
00:31:03,166 --> 00:31:03,766
what can,

1287
00:31:03,766 --> 00:31:05,600
you know, breathing calmly do for me?

1288
00:31:05,600 --> 00:31:07,300
But you think, well,

1289
00:31:07,300 --> 00:31:08,366
if one thing is true,

1290
00:31:08,366 --> 00:31:10,566
like if we know that things damage cells,

1291
00:31:10,566 --> 00:31:12,766
I imagine the opposite can be true,

1292
00:31:12,766 --> 00:31:15,100
which is those cells become regenerative

1293
00:31:15,100 --> 00:31:16,700
the more you're taking care of yourself.

1294
00:31:16,700 --> 00:31:19,066
It doesn't seem that farfetched.

1295
00:31:19,066 --> 00:31:20,266
Stress reduction,

1296
00:31:20,266 --> 00:31:21,300
sleep improvement,

1297
00:31:21,300 --> 00:31:22,666
all of these things are huge

1298
00:31:22,666 --> 00:31:23,366
things that you can do

1299
00:31:23,366 --> 00:31:24,966
to help yourself with outcomes.

1300
00:31:24,966 --> 00:31:26,166
So you have this group

1301
00:31:26,166 --> 00:31:27,700
that sort of supports

1302
00:31:27,700 --> 00:31:30,266
overall lifestyle changes.

1303
00:31:30,266 --> 00:31:31,766
And we also offer psychosocial

1304
00:31:31,766 --> 00:31:34,166
support because it is a huge

1305
00:31:35,366 --> 00:31:35,966
thing

1306
00:31:35,966 --> 00:31:37,566
to be told you... It's a huge life event. A

1307
00:31:37,566 --> 00:31:38,700
huge life event to be told

1308
00:31:38,700 --> 00:31:39,600
you have a breast cancer.

1309
00:31:39,600 --> 00:31:40,600
It feels like

1310
00:31:40,600 --> 00:31:42,166
your body has turned against you.

1311
00:31:42,166 --> 00:31:43,300
And most of these patients

1312
00:31:43,300 --> 00:31:44,666
are otherwise healthy.

1313
00:31:44,666 --> 00:31:45,566
So they're coming in

1314
00:31:45,566 --> 00:31:47,766
with this surprise news

1315
00:31:47,766 --> 00:31:49,466
and it's devastating.

1316
00:31:49,466 --> 00:31:53,066
So it is completely natural to need and

1317
00:31:53,066 --> 00:31:55,266
and want some support in that regard.

1318
00:31:55,266 --> 00:31:56,366
And so we offer that here as well.

1319
00:31:56,366 --> 00:31:56,966
That's wonderful

1320
00:31:56,966 --> 00:31:57,566
because you

1321
00:31:57,566 --> 00:31:59,066
especially would want that support,

1322
00:31:59,066 --> 00:31:59,466
I imagine,

1323
00:31:59,466 --> 00:32:01,266
from somebody who

1324
00:32:01,266 --> 00:32:02,766
focuses on this as opposed to,

1325
00:32:02,766 --> 00:32:03,100
you know,

1326
00:32:03,100 --> 00:32:03,866
maybe a therapist

1327
00:32:03,866 --> 00:32:04,766
who means well and just goes,

1328
00:32:04,766 --> 00:32:05,666
this must be so awful,

1329
00:32:05,666 --> 00:32:07,266
I have no idea what you're going through.

1330
00:32:07,266 --> 00:32:08,966
That's one way.

1331
00:32:08,966 --> 00:32:11,766
But to come in, for somebody to already

1332
00:32:11,766 --> 00:32:13,266
be sort of in this world

1333
00:32:13,266 --> 00:32:14,766
and help guide you around

1334
00:32:14,766 --> 00:32:17,366
this new territory makes so much sense.

1335
00:32:17,366 --> 00:32:18,966
So obviously, as a woman, I'm

1336
00:32:18,966 --> 00:32:20,666
incredibly grateful that you chose

1337
00:32:20,666 --> 00:32:22,866
to go into breast cancer surgery,

1338
00:32:22,866 --> 00:32:23,766
but I'm wondering why.

1339
00:32:23,766 --> 00:32:24,366
I mean, there's

1340
00:32:24,366 --> 00:32:25,566
there's all kinds of cancers.

1341
00:32:25,566 --> 00:32:26,266
There's all kinds of ways

1342
00:32:26,266 --> 00:32:27,266
to help people. Was this...

1343
00:32:27,266 --> 00:32:29,566
Was there a specific reason for you?

1344
00:32:29,566 --> 00:32:31,366
Yes. So, absolutely.

1345
00:32:31,366 --> 00:32:32,500
So I, I knew that

1346
00:32:32,500 --> 00:32:34,466
I wanted to work in cancer surgery

1347
00:32:34,466 --> 00:32:37,366
actually as a resident. Very early on. I just,

1348
00:32:37,366 --> 00:32:38,666
I loved the pathology.

1349
00:32:38,666 --> 00:32:40,566
I really loved the patients.

1350
00:32:40,566 --> 00:32:42,166
I liked being able to offer them

1351
00:32:42,166 --> 00:32:43,666
an opportunity for cure.

1352
00:32:43,666 --> 00:32:45,066
And then

1353
00:32:45,066 --> 00:32:46,566
in my surgical oncology fellowship,

1354
00:32:46,566 --> 00:32:47,266
where I got exposure

1355
00:32:47,266 --> 00:32:47,966
to all different types

1356
00:32:47,966 --> 00:32:49,266
of cancer surgeries,

1357
00:32:49,266 --> 00:32:50,166
I really fell in love

1358
00:32:50,166 --> 00:32:51,866
with the breast cancer population.

1359
00:32:51,866 --> 00:32:52,900
I just,

1360
00:32:52,900 --> 00:32:53,866
I loved that

1361
00:32:53,866 --> 00:32:55,700
the patients overall did well,

1362
00:32:55,700 --> 00:32:56,900
that they would come to you

1363
00:32:56,900 --> 00:32:57,700
in this vulnerable

1364
00:32:57,700 --> 00:32:58,700
time in their life,

1365
00:32:58,700 --> 00:33:01,466
and you as a surgeon could fix it.

1366
00:33:01,466 --> 00:33:01,866
It was like,

1367
00:33:01,866 --> 00:33:02,300
it was part of

1368
00:33:02,300 --> 00:33:03,566
what drew me to surgery to begin with

1369
00:33:03,566 --> 00:33:04,966
is the ability to fix a problem,

1370
00:33:04,966 --> 00:33:07,866
because surgery has such acute issues

1371
00:33:07,866 --> 00:33:08,366
that you can

1372
00:33:08,366 --> 00:33:10,066
then solve... Do something about.

1373
00:33:10,066 --> 00:33:10,866
With something with that

1374
00:33:10,866 --> 00:33:12,100
you do with your hands, right?

1375
00:33:12,100 --> 00:33:13,366
That being able to

1376
00:33:13,366 --> 00:33:14,666
fix somebody's problem,

1377
00:33:14,666 --> 00:33:16,366
let them go on with their life

1378
00:33:16,366 --> 00:33:17,300
and then have this

1379
00:33:17,300 --> 00:33:18,966
longitudinal relationship with them

1380
00:33:18,966 --> 00:33:20,566
just was perfect.

1381
00:33:20,566 --> 00:33:22,300
I was just like, this is a dream job.

1382
00:33:22,300 --> 00:33:23,266
Then I get to be friends

1383
00:33:23,266 --> 00:33:25,766
with that patient for, for years.

1384
00:33:25,766 --> 00:33:27,766
So so I think that's what really kind of

1385
00:33:27,766 --> 00:33:29,066
was the final,

1386
00:33:29,066 --> 00:33:29,366
you know,

1387
00:33:29,366 --> 00:33:31,266
decision maker for me

1388
00:33:31,266 --> 00:33:33,100
for going into breast surgery.

1389
00:33:33,100 --> 00:33:35,466
Doctor Alexandra Lopez Aguilar,

1390
00:33:35,466 --> 00:33:36,666
you're amazing.

1391
00:33:36,666 --> 00:33:39,100
Thank you so much for sharing your time,

1392
00:33:39,100 --> 00:33:40,300
your expertise with us.

1393
00:33:40,300 --> 00:33:41,866
This actually, I,

1394
00:33:41,866 --> 00:33:42,566
you know the phrase

1395
00:33:42,566 --> 00:33:44,666
all information is good information.

1396
00:33:44,666 --> 00:33:45,500
So even if it's

1397
00:33:45,500 --> 00:33:47,166
kind of a scary subject,

1398
00:33:47,166 --> 00:33:49,300
I hope other people feel as

1399
00:33:50,266 --> 00:33:51,066
comfortable and

1400
00:33:51,066 --> 00:33:52,466
confident as I do

1401
00:33:52,466 --> 00:33:53,700
now after talking to you,

1402
00:33:53,700 --> 00:33:55,300
just having that information.

1403
00:33:55,300 --> 00:33:56,466
So thank you again.

1404
00:33:56,466 --> 00:33:57,900
We really, really appreciate it.

1405
00:33:57,900 --> 00:33:58,966
Thank you so much for having me.

1406
00:33:58,966 --> 00:33:59,900
It was a pleasure.
