Dr. Maheswari Senthil is a UCI Health surgeon who specializes in treating cancers of the gastric system, including the cancers of the appendix and peritoneum.

Maheswari Senthil, MD


Surgical Oncology, General Surgery

Clinical Interests

appendix tumors, Gastric cancer, gastrointestinal stromal tumors, melanoma, mesothelioma, peritoneal carcinomatosis (colon, gastric and appendix cancers), retroperitoneal sarcoma, Soft tissue sarcomas

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  • American Board of Surgery, Surgery
  • English
  • Tamil
Medical School
Madurai Medical College, Madurai, India
University of Medicine and Dentistry of New Jersey, Newark, NJGeneral Surgery
City of Hope, Duarte, CASurgical Oncology
Professional Positions
  • Professor — Division of Surgical Oncology, Department of Surgery, UCI School of Medicine
  • Interim Medical Director — Oncology Services, Chao Family Comprehensive Cancer Center
  • Interim Chief — Division of Surgical Oncology, Department of Surgery
  • Director — Peritoneal malignancies program, Department of Surgery
  • Co-director — Melanoma program, Department of Surgery
  • Member — American College of Surgeons
  • Member — Alpha Omega Alpha
  • Member — Society of Surgical Oncology
  • Member — American Association of Cancer Research
  • Member — American Cancer Society, Southern California chapter
  • Member — Pacific Coast Surgical Association
  • Member — American Medical Association
  • Member — Gastrointestinal Committee, SWOG (July 2019-present)
  • Member — Peritoneal Disease Working Committee, Society of Surgical Oncology (July 2018-present)
  • Member — HIPEC Working Group, ECOG-ACRIN Cancer Research Group (February 2016-present)
Awards and Recognition
  • 2021 John Connolly Teacher of the Year Award, Department of Surgery, UCI School of Medicine
  • Healing Hands award — Loma Linda University Health, 2017, 2018
  • Excellence in Education — Loma Linda University Health
More Information

Dr. Maheswari Senthil is a board-certified UCI Health surgical oncologist who specializes in the management of advanced gastrointestinal cancers, peritoneal malignancies, sarcomas, neuroendocrine tumors and melanomas.

A leader in the management of peritoneal carcinomatosis, she offers targeted systemic treatments combined with cytoreduction surgery and intraperitoneal chemotherapy to patients with stage IV gastrointestinal cancer. 

Senthil earned her medical degree at Madurai Medical College in Madurai, India. She completed a residency in general surgery at University of Medicine and Dentistry of New Jersey in Newark, and a fellowship in surgical oncology at City of Hope in Duarte, Calif. She is the director of the peritoneal malignancy program and co-director of the melanoma program at the UCI School of Medicine's Department of Surgery.

Her research interests include the design and execution of clinical trials to test treatment approaches for managing advanced cancers. She also is studying novel blood-based liquid-biopsy techniques for early cancer detection.

Through bench-to-bedside translational research and technical excellence, Senthil seeks to improve the diagnosis and treatment of patients with advanced cancers. Her focus is on healing the body as well as the mind and spirit.

She sees patients at UCI Health Chao Family Comprehensive Cancer Center in Orange.

UCI Health Chao Family Comprehensive Cancer Center
101 The City Drive South, Building 23
Orange, CA 92868
Phone: 714-456-8000
Fax: 855-211-3729