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RepurposingRiluzoleAugmentBrainDerivedNeuropathFactorLevel&CogFunc BreastCaPa ExpCa-Related CogImpai

UCI Specialty Area: Cancer
Principal Investigator: Alexandre Chan
Official Title: Repurposing Riluzole for Augmenting Brain-Derived Neuropathic Factor (BDNF) Levels and Cognitive Function in Patients Experiencing Cancer-Related Cognitive Impairment: An Interventional Pilot Clinical Trial
A Study On:
Breast

Study Description

This is a phase 2a, randomized, double-blinded, placebo-controlled pilot clinical trial determining the impact of riluzole therapy on circulating brain derived neuropathic factor (BDNF) levels of cancer survivors with cancer related cognitive impairment.

Eligibility

• Diagnosed with one of the following:

• Breast cancer exposed to treatment including chemotherapy, radiotherapy, surgery, and/or other breast cancer interventions

• Non-breast cancer patients exposed to anthracyclines- or platinum-containing chemotherapy within the past 3 years

• Non-breast cancer patients exposed to other anticancer therapies within the past 3 years

• ≥18 years of age

• Perceived that cognitive function has worsened since cancer diagnosis and/or beginning of cancer treatment

• Able to provide informed consent

• Must agree to complete and able to complete the questionnaires and computerized assessments

• Presence of brain metastases

• Unwilling to undergo neuropsychological assessments necessary for the study

• Breastfeeding, pregnant or are planning get pregnant during the study period

• History of or suspected hypersensitivity to riluzole or to any of its inactive ingredients

• Patients taking or planning to take medications/substances with potential drug-drug interactions

• Hepatic impairment: Patients with measured serum transaminases 3 times greater than upper limit of normal

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University of California, Irvine - Study Information Sheet

UCI Center for Clinical Research Potential Participant Database

Lead Researcher
Maheswari Senthil, MD
UCI Center for Clinical Research

In the instance of parental permission, “You” refers to “Your child.”

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