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Vascular disease

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A Phase 2 Study of Poziotinib in Patients with Non-Small Cell Lung Cancer, Locally Advanced or Metastatic, with EGFR or HER2 Exon 20 Insertion Mutation (POZITIVE20-1)

Sai-Hong Ignatius Ou
Open

A Phase 2, Open-Label, Single-Arm, Multicenter Study to Evaluate the Efficacy and Safety of INCB054828 in Subjects With Advanced/Metastatic or Surgically Unresectable Cholangiocarcinoma Including FGFR2 Translocations Who Failed Previous Therapy

David Imagawa
Open

A Phase 2, Proof-of-Concept, Double-Blind-Randomized, Placebo-Controlled Adaptive Design Trial of Nicotinamide in MCI Due to AD and Mild AD Dementia

This research study seeks participants to evaluate if nicotinamide can reduce phosphorylation in subjects with mild cognitive impairment or mild...
Joshua Grill, PhD, and Aimee Pierce, MD

UCI campus (1100 Gottschalk Medical Plaza, Irvine; ICTS at Hewitt Hall, Irvine and Newport Diagnostic Center, Newport Beach); UCLA Center for Neurotherapeutics (UCLA Medical Center, 300 Medical Plaza, Westwood Blvd., Los Angeles).

A Phase 2, randomized, double-blind, placebo-controlled, dose-finding study to evaluate the safety, tolerability, and efficacy of KD025 in adult subjects with moderate to severe chronic plaque psoriasis who are candidates for systemic therapy or phototherapy

Natasha Mesinkovska, MD, PhD

At the UC Irvine campus:
Dermatology Clinical Research Center
843 Health Science Road
Hewitt Hall, Room 1001
Irvine, CA 92697

Open

A Phase 2/3 Multicenter, Open-label, 3-arm, 2-Stage Randomized Study of ASP2215 (Gilteritinib), Combination of ASP2215 Plus Azacitidine and Azacitidine Alone in the Treatment of Newly Diagnosed Acute Myeloid Leukemia With FLT3 Mutation in Patients Not Eligible for Intensive Induction Chemotherapy

Deepa Jeyakumar
Open

A Phase 2b Randomized Study to Assess the Efficacy and Safety of the Combination of Ublituximab + TGR-1202 with or without Bendamustine and TGR-1202 alone in Patients with Previously Treated Non-Hodgkin’s Lymphoma

Lauren C Pinter-Brown
Open

A Phase 2b/3 Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Study Investigating the Efficacy and Safety of JNJ-54861911 in Subjects Who Are Asymptomatic at Risk for Developing Alzheimer's Dementia

This research study seeks participants to study the efficacy and safety of JNJ-54861911 in those who are asymptomatic at risk for developing...
Aimee L. Pierce, MD

UCI campus (UCI MIND Gottschalk Medical Plaza, ICTS in Hewitt Hall Neuroscience Imaging Center in Irvine Hall) in Irvine

A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Aducanumab (BIIB037) in Subjects with Early Alzheimer's Disease

This research study seeks participants to study the efficacy and safety of aducanumab in subjects with early Alzheimer's disease.
Aimee Pierce, MD

UCI campus (UCI MIND Gottschalk Medical Plaza, ICTS in Hewitt Hall, Neuro Imaging Center), Newport Diagnostic Center

A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-controlled Study of AG-120 in Previously-treated Subjects with Nonresectable or Metastatic Cholangiocarcinoma with an IDH1 Mutation

Farshid Dayyani
Open

A Phase 3, Randomized, Open-Label Study to Evaluate the Efficacy and Safety of Eflornithine with Lomustine Compared to Lomustine Alone in Patients with Anaplastic Astrocytoma That Progress/Recur After Irradiation and Adjuvant Temozolomide Chemotherapy

Daniela Bota
Open