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Dr. Seyed Mohammad H. Shafie is a UCI Health neurologist who specializes in vascular neurology.

S. Mohammad H. Shafie, MD, PhD


Vascular Neurology, Neurology

Clinical Interests

cerebral aneurysm, cerebral arterial atherosclerotic disease, cerebral arteriovenous malformations, cerebral microvascular ischemic disease, cerebral venous thrombosis (carotid artery disease), intracerebral hemorrhage, ischemic stroke, transient ischemic attack (TIA), vascular dementia

Nickname: Mohammad
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  • American Board of Psychiatry and Neurology, Neurology
  • American Board of Psychiatry and Neurology, Vascular Neurology
  • English
  • Farsi
Medical School
Virginia Commonwealth University School of MedicineMD
Union Memorial HospitalInternal Medicine
Harbor UCLA Medical CenterNeurology
UC Davis Medical CenterNeurology
Grad School
University of Louisville — PhD, Chemical Engineering
Professional Positions
  • Assistant Professor — Department of Neurology, UCI School of Medicine
  • Associate Director — UCI Health Comprehensive Stroke and Cerebrovascular Center
  • Director — Vascular Neurology Fellowship Program, Department of Neurology
Awards and Recognition
  • Physicians of Excellence, Orange County Medical Association — 2022
More Information

Dr. S. Mohammad Shafie is a board-certified UCI Health vascular neurologist who specializes in the the management of stroke and cerebrovascular diseases. He serves as associate director of the UCI Health Comprehensive Stroke and Cerebrovascular Center

Shafie received a medical degree from the Virginia Commonwealth University School of Medicine in Richmond, Va. He completed an internal medicine internship at MedStar Union Memorial Hospital in Baltimore, Md., followed by a residency in neurology at Harbor-UCLA Medical Center in Torrance. Next, he received fellowship training in vascular neurology at Cedars-Sinai Medical Center in Los Angeles. Before medical school, he earned master's and doctoral degrees in chemical engineering with a focus on bioengineering at the University of Louisville in Louisville. Ky.

His research interests include translational and clinical investigations aimed at improving the prevention, diagnosis and treatment of the entire spectrum of cerebrovascular diseases. He is the principal investigator and co-investigator of multiple StrokeNet clinical trials sponsored by the National Institutes of Health and private industry. He serves as fellowship director of vascular neurology for the UCI School of Medicine's Department of Neurology and is actively involved in the teaching of medical students, residents and fellows.

Shafie, who speaks Farsi, sees patients in Orange and Irvine.

UCI Health Gottschalk Medical Plaza
1 Medical Plaza Drive
Irvine, CA 92697
Phone: 949-824-8600
Fax: 855-209-8413
UCI Health Neurology Services
UCI Medical Center, Pavilion 1
101 The City Drive South, Building 30
Orange, CA 92868
Phone: 714-456-7720
Fax: 855-209-8413