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PhIIIMirvetuximabSoravtansineCombW/BevacizumabVSBevacizumab PaW/FrA+After2ndLine PlatinumChemo +Bev

UCI Specialty Area: Cancer
Principal Investigator: Krishnansu Tewari
Official Title: Randomized, Multicenter, Open-label, Phase III Study of Mirvetuximab Soravtansine in Combination With Bevacizumab Versus Bevacizumab Alone as Maintenance Therapy for Patients With FrA-positive Recurrent Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancers Who Have Not Progressed After Second Line Platinum-based Chemotherapy Plus Bevacizumab
A Study On:
Cervix
Corpus Uteri
Other Female Genital
Ovary

Study Description

Randomized, multicenter, open-label, Phase 3 study of mirvetuximab

soravtansine in combination with bevacizumab versus bevacizumab

alone as maintenance therapy for patients with FRα-high recurrent

platinum-sensitive epithelial ovarian, fallopian tube, or primary

peritoneal cancers who have not progressed after second-line platinumbased

chemotherapy plus bevacizumab (GLORIOSA)

Eligibility

  • Patients must be <18 years of age.
  • Patients must have an Eastern Cooperative Oncology Group performance status of 0 or 1.
  • Patients must have a confirmed diagnosis of high-grade serous epithelial ovarian, primary

peritoneal, or fallopian tube cancer

  • Patients with PD while on or following platinum-based triplet therapy
  • Patients with prior wide-field radiotherapy affecting at least 20% of the bone marrow
  • Patients with > Grade 1 peripheral neuropathy per Common Terminology Criteria for

Adverse Events (CTCAE)

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Privacy Policy

University of California, Irvine - Study Information Sheet

UCI Center for Clinical Research Potential Participant Database

Lead Researcher
Maheswari Senthil, MD
UCI Center for Clinical Research

In the instance of parental permission, “You” refers to “Your child.”

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  • Future Research Use
    Researchers will use your information to conduct this study. Once the study is done using your information, we may share them with other researchers so they can use them for other studies in the future. We will not share your name or any other private identifiable information that would let the researchers know who you are. We will not ask you for additional permission to share this de-identified information
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