A Phase II Study of Loncastuximab Tesirine and Rituximab (Lonca-R) Followed by DAEPOCH-R in Previously Untreated High-risk Diffuse Large B-cell Lymphoma
The purpose of this study is to find the safest most effective treatment with the combination of
loncastuximab tesirine plus rituximab followed by dose-adjusted doxorubicin, etoposide, vincristine,
cyclophosphamide, and prednisone (DA-EPOCH-R). The study is being done to see if this treatment is
effective in treatment of high-risk lymphomas such as the participants.
Eligibility
Age 18+
Life expectancy >6 months
-Measurable disease by CT or PET/CT scan, with one or more sites of disease >1.5 cm in longest dimension
-History of allergic reactions attributed to compounds of similar chemical or biologic composition to other agents used in study
-Breastfeeding or pregnancy
-Known active tuberculosis (TB)
Interested in Participating in this Trial?
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Privacy Policy
University of California, Irvine - Study Information Sheet
UCI Center for Clinical Research Potential Participant Database
Lead Researcher
Eric Vilain, MD, PhD
UCI Center for Clinical Research
In the instance of parental permission, “You” refers to “Your child.”
Please read the information below and ask questions about anything that you do not understand. A
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Future Research Use
Researchers will use your information to conduct this study. Once the study is done using your
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Data Retention - In accordance with UC Office of the President policy, information will be retained for
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