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doctor uses stethoscope to listen to senior women's heart

Cardiac Amyloidosis Services

Amyloidosis is an underdiagnosed disorder involving the buildup of abnormal protein deposits, called amyloid fibrils, in various body organs. These amyloid fibrils then become directly toxic to the organs, disrupting their organ functions. 

Amyloid deposits in heart tissue can lead to a stiffening of the heart muscle and affect its ability to beat normally and pump blood. Amyloidosis may also attack the kidneys, liver, spleen, digestive tract, brain and nervous system. An estimated 4,000 people in the United States are diagnosed with the disease each year, but that may be an undercount, according to the National Organization for Rare Disorders (NORD). 

This multi-organ disease benefits from early diagnosis and treatment to help prevent further organ damage. UCI Health has established Orange County's first multidisciplinary team to evaluate and treat amyloidosis. 

Our evaluation includes assessments of the heart, kidney, gastrointestinal, blood, nervous system and other organ involvement. Treatment varies depending on the organ systems affected.

For a complete evaluation, call 714-456-6699 to make an appointment. 

As Orange County's only academic health system, UCI Health has the expertise and resources to provide state-of-the-art care for patients with amyloidosis, a little-understood disorder often mistaken for other conditions.

Led by UCI Health cardiologist Dr. Roxana Ghashghaei, who also has expertise in echocardiography and nuclear medicine, we apply the latest clinical advances, cardiac imaging and testing technologies to develop a comprehensive diagnosis and treatment plan for cardiac amyloidosis.

Working with our network of UCI Health cardiologists, nephrologists, neurologists, hematologists/oncologists and gastrointestinal specialists, we also are uniquely able to deliver treatment across multiple disciplines, providing each patient with a personalized approach to care.


A diagnosis of cardiac amyloidosis is often delayed because early symptoms may suggest heart failure. These include: 

  • Shortness of breath
  • Dizziness
  • Fainting
  • Fatigue
  • Swelling in the legs
  • Fluttering or pounding heart
  • Low blood pressure


Medication to stabilize the proteins and prevent further progression of amyloid deposits. 

Our experienced cardiologists work with a highly skilled, multidisciplinary team to provide you with the best possible care.

Our team includes:






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