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Movement Disorders

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A Randomized (1:1), Double-Blind, Multi-Center, Placebo Controlled Study Evaluating Intensive Chemotherapy With or Without Glasdegib (PF-04449913) or Azacitidine (AZA) With or Without Glasdegib in Patients with Previously Untreated Acute Myeloid Leukemia

Susan O'Brien
Open

A Randomized, Double-Blinded, Placebo-Controlled Phase II Study of (ERC1671/ GM-CSF / Cyclophosphamide) + Bevacizumab versus (Placebo Injection / Placebo pill) + Bevacizumab in the Treatment of Recurrent/Progressive, Bevacizumab Naïve Glioblastoma Multiforme and Gliosarcoma Patients (WHO Grade IV Malignant Gliomas)

Daniela Bota
Open

A Randomized, Placebo Surgery Controlled, Double-Blinded, Multi-Center, Phase 2 Clinical Trial, Evaluating the Efficacy and Safety of VY-AADC02 in Advanced Parkinson's Disease with Motor Fluctuations (RESTORE-1)

Anna Morenkova, MD, PhD

UCI Main Campus Irvine, CA; UCSF Medical Center San Francisco, CA; San Francisco Veteran's Affairs Medical Center, San Francisco, CA

A Sequential 2-arm, Open-label Phase I Study to Evaluate the Effects of Encorafenib in Combination with Binimetinib on the Pharmacokinetics of Losartan, Midazolam, Caffeine, Omeprazole, and Dextromethorphan Administered in a Cocktail Approach and on the Pharmacokinetics of Rosuvastatin in Patients with BRAF V600-mutant Unresectable or Metastatic Melanoma or Other Advanced Solid Tumors

John P Fruehauf
Open

A Single-Arm, Open-Label, Multicenter Study of Enfortumab Vedotin (ASG-22CE) for Treatment of Patients with Locally Advanced or Metastatic Urothelial Cancer who Previously Received Immune Checkpoint Inhibitor (CPI) Therapy

Nataliya Mar
Open

A cross-sectional study of renal function in treatment-naive young male patients with Fabry disease

Virginia Kimonis, MD

UC Irvine Institute for Clinical and Translational Science, Irvine campus

A double-blind, controlled phase 2 study of the safety and efficacy of modified stem cells (SB623) in patients with chronic motor deficit from traumatic brain injury (TBI)

Participants are needed for this stem cell research study that will evaluate an investigational therapy in hopes of improving motor function after...
Leonid Groysman, MD

Study visits will take place at Hewitt Hall on the UCI campus and at UC Irvine Medical Center in Orange. The surgery will take place at UC Irvine Medical Center.

Open

A multicenter prospective clinical trial to evaluate the safety and effectiveness of the CT LUCIA 611P posterior chamber intraocular lens for correction of aphakia following cataract removal

Sumit (Sam) Garg, MD

UCI Health Gavin Herbert Eye Institute, 850 Health Sciences Road, Irvine, CA 92697

A multinational phase 3, randomized, open-label, parallel group study to evaluate the safety and efficacy of relugolix in men with advanced prostate cancer (HERO)

Edward Uchio
Open

A phase 2, single-arm, two-period study of sodium cridanimod in conjunction with progestin therapy in patients with endometrial carcinoma

UCI Health Chao Family Comprehensive Cancer Center is conducting a phase 2, single-arm, two-period study of sodium cridanimod in conjunction with...
Krishnansu Tewari, MD
Open