Dr. Jefferson W. Chen is a board-certified UCI Health neurosurgeon who specializes in neurological trauma and critical care, brain tumor and stroke.

Jefferson W. Chen, MD


Neurological Surgery

Clinical Interests

brain tumors, normal pressure hydrocephalus, stroke and stroke recovery, traumatic brain injury

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  • American Board of Neurological Surgery, Neurological Surgery
  • United Council for Neurologic Subspecialties, Neurocritical Care
  • United Council for Neurologic Subspecialties, Neuro-Oncology
  • English
Medical School
Johns Hopkins University School of Medicine, MD/PhD program
UC San Diego Medical CenterGeneral Surgery
Children's Hospital of Los AngelesPediatric Neurosurgery
UC San Diego Medical CenterNeurological Surgery
St. Joseph's Hospital and Medical CenterNeurovascular/Skull Base Neurosurgery
Professional Positions
  • Professor — Department of Neurological Surgery
  • Vice-Chair — Clinical Affairs, Department of Neurological Surgery
  • Director — Neurological Trauma, Neurosurgery Services
  • Fellow — American Association of Neurological Surgeons
  • Fellow — American College of Surgeons
  • Fellow — American College of Critical Care Medicine
  • Member — National Hydrocephalus Foundation Medical Advisory Board
  • Member — American Heart Association, Stroke Council
  • Member — Congress of Neurological Surgeons
  • Member — International NeuroTrauma Society
  • Member — NeuroCritical Care Society
  • Member — Society of Critical Care Medicine
  • Member — California Association of Neurological Surgeons
  • Member — Western Neurosurgical Society
  • Member — American Medical Association
Awards and Recognition
  • Physicians of Excellence, Orange County Medical Association — 2020-2023
  • Best Doctors in America® — Neurological Surgery, 2007, 2010-2013, 2015, 2016
  • ARIISE Award for Innovation — UCI Health, 2017
  • Medical Scientist Training Program (MSTP) — National Institutes of Health
More Information

Dr. Jefferson W. Chen is a board-certified UCI Health neurosurgeon. His clinical interests include neurological trauma and critical care, normal pressure hydrocephalus, stroke and brain tumors. He is a leader in such techniques as multimodal brain monitoring for traumatic brain injury and the use of BrainPath® technology to access deep-seated lesions.

Chen earned his PhD and medical degrees from Johns Hopkins School of Medicine. He completed residencies in general and neurological surgery at UC San Diego. He also completed a fellowship in neurovascular and skull base surgery at Barrow Neurological Institute of St. Joseph’s Hospital and Medical Center in Phoenix.

His research endeavors include studying the molecular mechanisms and biochemical underpinnings of traumatic brain injury, stroke and the flow of fluids through the brain.

He sees patients at UCI Medical Center in Orange.

UCI Health Neurosurgery Services
101 The City Drive South, Pavilion 1
Building 30
Orange, CA 92868
Phone: 714-456-6966
Fax: 855-209-8413