A Phase III, Randomized, Open-Label, Multicenter Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) in Combination with Pembrolizumab with or without Bevacizumab Compared with Standard of Care as Firstline Maintenance Treatment for Participants with Persistent, Recurrent, or Newly Diagnosed Metastatic Cervical Cancer with PD-L1 CPS Greater Than or Equal to 1 (TroFuse-036/GOG-3123/ENGOT-cx22)
The purpose of this research is to look at how safe and how well Sacituzumab Tirumotecan (sac-TMT) works in combination with pembrolizumab with or without bevacizumab compared to standard treatment in people with persistent, recurrent or newly diagnosed metastatic cervical cancer.
Eligibility
Has a histologically confirmed diagnosis of squamous cell carcinoma, adenosquamous carcinoma, or adenocarcinoma of cervix.
Is assigned female sex at birth
-At least 18 years of age
HIV-infected participants with a history of Kaposi's sarcoma and/or Multicentric Castleman's Disease.
Received prior systemic anticancer therapy
Has received an investigational agent or has used an investigational device within 4 weeks prior to study intervention administration
Interested in Participating in this Trial?
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Privacy Policy
University of California, Irvine - Study Information Sheet
UCI Center for Clinical Research Potential Participant Database
Lead Researcher
Eric Vilain, MD, PhD
UCI Center for Clinical Research
In the instance of parental permission, “You” refers to “Your child.”
Please read the information below and ask questions about anything that you do not understand. A
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Future Research Use
Researchers will use your information to conduct this study. Once the study is done using your
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Data Retention - In accordance with UC Office of the President policy, information will be retained for
10 years after the end of the calendar year in which the research is completed.
If, during the course of this study, significant new information becomes available that may relate to
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