Neuromuscular

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A Phase 2, Proof-of-Concept, Double-Blind-Randomized, Placebo-Controlled Adaptive Design Trial of Nicotinamide in MCI Due to AD and Mild AD Dementia

This research study seeks participants to evaluate if nicotinamide can reduce phosphorylation in subjects with mild cognitive impairment or mild...
Joshua Grill, PhD, and Aimee Pierce, MD

UCI campus (1100 Gottschalk Medical Plaza, Irvine; ICTS at Hewitt Hall, Irvine and Newport Diagnostic Center, Newport Beach); UCLA Center for Neurotherapeutics (UCLA Medical Center, 300 Medical Plaza, Westwood Blvd., Los Angeles).

A Phase 2b/3 Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Study Investigating the Efficacy and Safety of JNJ-54861911 in Subjects Who Are Asymptomatic at Risk for Developing Alzheimer's Dementia

This research study seeks participants to study the efficacy and safety of JNJ-54861911 in those who are asymptomatic at risk for developing...
Aimee L. Pierce, MD

UCI campus (UCI MIND Gottschalk Medical Plaza, ICTS in Hewitt Hall Neuroscience Imaging Center in Irvine Hall) in Irvine

A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Aducanumab (BIIB037) in Subjects with Early Alzheimer's Disease

This research study seeks participants to study the efficacy and safety of aducanumab in subjects with early Alzheimer's disease.
Aimee Pierce, MD

UCI campus (UCI MIND Gottschalk Medical Plaza, ICTS in Hewitt Hall, Neuro Imaging Center), Newport Diagnostic Center

A Randomized, Placebo Surgery Controlled, Double-Blinded, Multi-Center, Phase 2 Clinical Trial, Evaluating the Efficacy and Safety of VY-AADC02 in Advanced Parkinson's Disease with Motor Fluctuations (RESTORE-1)

Anna Morenkova, MD, PhD

UCI Main Campus Irvine, CA; UCSF Medical Center San Francisco, CA; San Francisco Veteran's Affairs Medical Center, San Francisco, CA

A cross-sectional study of renal function in treatment-naive young male patients with Fabry disease

Virginia Kimonis, MD

UC Irvine Institute for Clinical and Translational Science, Irvine campus

A multicenter prospective clinical trial to evaluate the safety and effectiveness of the CT LUCIA 611P posterior chamber intraocular lens for correction of aphakia following cataract removal

Sumit (Sam) Garg, MD

UCI Health Gavin Herbert Eye Institute, 850 Health Sciences Road, Irvine, CA 92697

A phase 2a, randomized, double-blind, placebo-controlled study of the safety and efficacy of fenofibrate as a treatment for Huntington's disease

This research study seeks participants to study the safety and efficacy of the drug fenofibrate as a treatment for Huntington's disease.
Neal Hermanowicz, MD

Gottschalk Medical Plaza and Institute for Clinical and Translational Sciences (ICTS), UC Irvine campus