UCI Health will see you now: Welcome to our new co-workers and patients from Fountain Valley, Lakewood, Los Alamitos and Placentia Linda! 

Tahseen Mozaffar

Tahseen Mozaffar, MD


Neurology, Neuromuscular Medicine

Clinical Interests

electrodiagnostic medicine, nerve and muscle pathology, neurogenetic disorders

MyChart patient portal offers a convenient and secure way to manage your healthcare online. Use MyChart to schedule appointments, request prescription renewals, send messages to your care team and more.
  • American Board of Psychiatry and Neurology, Neurology - General
  • American Board of Psychiatry and Neurology, Neuromuscular Medicine [P&N]
  • English
  • Urdu
  • Hindi
Medical School
Aga Khan University
Aga Khan UniversityNeurology
St. Luke's HospitalMedicine internship
Barnes Hospital - Washington School of MedicineNeurology residency
Washington UniversityNeuromuscular Fellowship
Professional Positions
  • Professor — Department of Neurology, UCI School of Medicine
  • Director — UCI Health ALS & Neuromuscular Center
  • Director — annual UCI Neuromuscular Colloquia
  • Director — annual Neuromuscular Pathology Colloquium
  • Member — Myositis Association Medical Advisory Board
Awards and Recognition
  • Physicians of Excellence, Orange County Medical Association — 2012-2023
  • Best Doctors in America®, Neurology — 2015, 2016, 2017-2018
  • America's Top Doctors (Amyotrophic Lateral Sclerosis, Myasthenia Gravis, Neuromuscular Disorders), Castle Connolly Medical Ltd. — 2013
More Information

Dr. Tahseen Mozaffar is a board-certified UCI Health neurologist who specialize in neuromuscular disorders, including amyotrophic lateral sclerosis (ALS), myasthenia gravis, inflammatory myopathies, Pompe disease, muscle pathology and all types of muscular dystrophies.

He serves as director of the UCI Health ALS & Neuromuscular Center, one of only six Muscular Dystrophy Association-designated centers in California.

Mozaffar earned his medical degree at the Aga Khan University in Karachi, Pakistan, where he completed a rotating internship in internal medicine and general surgery. He completed a neurology residency at Barnes-Jewish Hospital in St. Louis, Mo., followed by a fellowship in neuromuscular disorders at Washington University, also in St. Louis.

His research focus includes clinical and translational studies of neuromuscular disorders and he is the principal site investigator of more than a dozen clinical trials for myasthenia gravis, immune myopathies and rare and ultra-rare myopathies. He is also the lead UCI investigator for NeuroNEXT, a collaborative national effort to help streamline phase 2 clinical trials for brain disorders that is supported by the National Institute of Neurological Disorders and Stroke (NINDS).

As an expert in rare and ultra-rare myopathies, he advises many pharmaceutical companies on clinical trial design and the identification of disease targets. He serves on a Pompe disease advisory board for Amicus Therapeutics and Spark Therapeutics, as well as on the data safety monitoring board for Acceleron and Sarepta Therapeutics. He also is a reviewer with the Emerging Technologies and Training in Neurosciences (ETTN) group for the National Institutes of Health (NIH). He has co-authored more than 175 peer-reviewed publications and has written or co-written more than a dozen book chapters and reviews.

Mozaffar, who is also fluent in Hindi and Urdu, sees patients in Irvine and Orange.

Academic Profile

View this physician's faculty profile ›

Speakers Bureau Topics

  • Amyotrophic Lateral Sclerosis (ALS), current knowledge
  • Diabetic Neuropathies Update
  • Electrodiagnostic Techniques in Orthopaedics, ENT and Rehab Medicine
  • Guillain-Barre Syndromes and Chronic Inflammatory Demyelinating Polyneuropathies (CIDP)
  • Immune-Mediated Myopathies: An Update
  • Immune-Mediated Neuropathies Update
  • Intravenous Immunoglobulin (IVIG), Uses and Abuses in Neurological Disorders
  • Muscular Dystrophies
  • Myasthenia Gravis, Management and Diagnosis
  • Neuromuscular Diseases Update

Joe C. Wen & Family Center for Advanced Care
19200 Jamboree Road
Irvine, CA 92612
Phone: 714-456-7002
UCI Health ALS & Neuromuscular Center
200 S. Manchester Ave., Suite 110
Orange, CA 92868
Phone: 714-456-2332
Fax: 714-456-5997