Raynaud's phenomenon is a disorder that causes decreased blood flow to the fingers. In some cases, it also causes less blood flow to the ears, toes, nipples, knees, or nose. This happens due to spasms of blood vessels in those areas. The spasms happen in response to cold, stress, or emotional upset.
Scleroderma is an ongoing (chronic) disease that causes abnormal growth of connective tissue. It can affect the joints, skin, and internal organs. It is degenerative and gets worse over time.
Systemic lupus erythematosus (lupus) is a disease that causes your body's immune system to attack its own cells and tissues. It causes periods of inflammation to various parts of the body. It can affect your joints, tendons, and skin. It can affect blood vessels. And it can affect organs, such as the kidneys, heart, lungs, and brain.
Sjögren syndrome is an autoimmune disorder. This means that the body's own immune system attacks its own cells and tissues by mistake. In this case, it attacks the glands that produce moisture. It commonly causes dry skin, dry eyes, and dry mouth.