Southern California Undiagnosed Diseases Program

At UCI Health, our undiagnosed diseases program is dedicated to helping you find answers when other tests have failed. UCI Health is a designated Center of Excellence by NORD (National Organization of Rare Diseases) and part of the Undiagnosed Diseases Network (UDN) funded by the National Institute of Health due to our expertise in diagnosing rare and ultra-rare conditions.

Our approach to undiagnosed diseases

The undiagnosed diseases program at UCI Health brings together a team of physician specialists and translational researchers to solve the most challenging medical mysteries. If you've been on a long diagnostic journey without clear answers, we're here to help.

We combine our clinical expertise with leading-edge research tools to provide comprehensive evaluations, focusing on rare and complex conditions. Our team leverages advanced molecular genomic tools, machine learning, and our broad expertise to uncover causes of unexplained symptoms.

Our ultimate goal is to find answers when the standard clinical practices have not worked.

Here's what you can expect:

Multidisciplinary teamwork

Our program coordinates experts from neurology, pediatrics, genetics, pathology, and more to provide a thorough evaluation.

Leading-edge diagnostics:

We use state-of-the-art tools, including long-read genomic sequencing, transcriptome sequencing, and artificial intelligence to explore potential diagnoses.

Personalized care

Our compassionate team works closely with you to understand your history and guide you through each step of your care.

 

Why choose UCI Health?

Unmatched diagnostic expertise

UCI Health is recognized for its high level of diagnostic expertise, made possible by our team of specialists and our access to advanced research tools. We provide answers for complex conditions that others can’t solve.

Innovative research and technology

We leverage UCI's extensive machine learning and AI infrastructure, along with leading-edge genomic technologies, to discover hidden causes of undiagnosed diseases. Our commitment to research advances both diagnosis and treatment.

Compassionate, multidisciplinary care

Our team understands the emotional and physical toll of a long diagnostic journey. We take a compassionate, personalized approach to your treatment, coordinating care across specialties to provide comprehensive support.