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Stop at nothing to prevent, treat and cure cancer — to save lives

Chao Family Comprehensive Cancer Center

At the UCI Health Chao Family Comprehensive Cancer Center, we help you fight cancer on all fronts. No cancer is rare to us.

As the only National Cancer Institute-designated comprehensive cancer center in Orange County, we treat more patients with cancer — and more complex cases — than any other healthcare provider in our region. We also offer the only adult hematopoietic stem-cell transplant services in Orange County, which means patients with leukemia, lymphoma and other cancers no longer need to travel long distances for this life-saving treatment.

We integrate research and the most advanced diagnostics, treatment and rehabilitation programs to give our patients the best possible care. With one of the largest early-phase clinical research programs in Southern California, our patients have access to promising therapies before they are available elsewhere.

Our world-class team of oncologists, surgeons, radiation oncologists, pathologists, nurses, rehabilitation therapists, pharmacists, social workers and dietitians works with cancers of all types and degrees of severity. Our primary service locations are in Orange, Costa Mesa and Yorba Linda.

To make an appointment, call 714-456-8000 or submit an appointment request form ›

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Located on the UCI Medical Center campus in Orange, the UCI Health Chao Family Comprehensive Cancer Center is affiliated with the UCI School of Medicine and the university's schools of basic sciences. These affiliations give our patients the expertise of a scientific community that is internationally renowned for its work in the prevention, diagnosis and treatment of cancer.

We are recognized for providing the highest quality care by the Quality Oncology Practice Initiative (QOPI) Certification Program, which is an affiliate of the American Society of Clinical Oncology.

We are also a Blue Distinction® Center for Complex and Rare Cancers. This designation is given by the Blue Cross Blue Shield Association to centers offering the full range of patient assessment, treatment planning, complex inpatient care and major surgical treatments for adults — all delivered by teams with distinguished expertise and subspecialty training for complex and rare cancers. Learn more about our Blue Distinction Center designation ›

Research-based care

The cancer center is one of only 51 National Cancer Institute (NCI)-designated comprehensive cancer centers in the United States, and the only one in Orange County. This recognition reflects our expertise in translating leading-edge scientific findings into clinical cancer treatment on all levels. It also underscores our commitment to cancer prevention research as well as our extensive community outreach and education programs.

We have one of the largest early-phase clinical research programs in Southern California, giving patients access to promising experimental medicines through clinical trials.

At the cancer center, you are cared for by a world-class team of cancer specialists, including medical oncologists, surgeons, radiation oncologists and pathologists, as well as highly trained nurses, rehabilitation therapists, pharmacists, social workers and dietitians.

Leading-edge technologies

You have access to the most advanced diagnostic and treatment technologies, including TrueBeam™ STx radiotherapy, a groundbreaking method of delivering powerful, targeted radiation faster and more precisely than with conventional radiotherapy.

Our modern infusion center allows our patients to undergo chemotherapy in privacy and comfort, attended by our team of experienced and compassionate nurses. 

Our cancer specialists are leaders in Orange County and Southern California in performing HIPEC, or hyperthermic intraoperative peritoneal chemotherapy, for late-stage and recurrent colorectal, gastric, ovarian and other cancers originating in the abdominal area.


As a comprehensive cancer center, we treat almost every type of cancer, including rare and aggressive forms that can afflict young people in the prime of their lives.

We emphasize a coordinated, patient-centered approach. This makes it easier for our multidisciplinary team of specialists to work together. It also streamlines the experience for patients and their families.

Personalized care

For cancer treatment to be effective, we believe treatment must be unique and personalized for each patient.

At the cancer center, each patient begins by undergoing a comprehensive clinical evaluation with a wide range of diagnostic technologies. These may include magnetic resonance imaging (MRI), computed tomography (CT) scans, positron emission tomography (PET) scans, endoscopy, X-rays and biopsies.

Our cancer specialists assess your condition and identify appropriate therapies as quickly as possible. We work closely with you and your family to discuss potential treatment options and encourage questions. One of our goals is to help you confront any fears and develop a proactive attitude that encourages healing.

Individualized treatment

Treatments and therapies may include surgery, radiation and chemotherapy, individually or in combination, depending on your personal health and the type and stage of your cancer. In some cases, patients may undergo treatment to reduce a tumor prior to surgery, an approach shown to improve survival and lower the rate of recurrence for some cancers.

During and after treatment, our cancer center dietitians, social workers and rehabilitation therapists work closely with you to support your recovery.

Cancer Support and Survivorship Services focuses on treating the whole patient, providing assistance with symptom management, supportive care and survivorship planning.

Clinical trials often compare the most accepted cancer treatments with new treatments that our physicians and researchers hope will be more effective.

At the UCI Chao Family Comprehensive Cancer Center, we have one of the largest early-phase clinical research programs in Southern California, giving patients access to promising experimental medicines in the very earliest studies. In the last decade, we have increased patient access to our more than 200 clinical trials by 90 percent.

Our researchers are at the forefront not only in treating cancer, but also in preventing it. Some of our clinical research is focused on prevention of breast, colon, esophageal, liver, pancreatic and prostate cancers, in both Phase 2 and Phase 3 clinical trials, as well as Phase 1 trials.

This means you may have access to new therapies for your condition years ahead of the general public.

Search our clinical trials ›

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